Overview

  • Product name

    Kawain, Natural kavalactone
  • Description

    Natural kavalactone. Various pharmacological activities.
  • Biological description

    Natural kavalactone. Various pharmacological activities including antinociceptive, analgesic, sedative and anticonvulsive activity. Active in vivo and orally bioavailable.
  • Purity

    > 98%
  • CAS Number

    3155-48-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Methoxy-2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one
  • Molecular weight

    230.26
  • Molecular formula

    C14H14O3
  • PubChem identifier

    5369129
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=O)OC(C1)C=CC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kormann EC  et al. Kavain analogues as potential analgesic agents. Pharmacol Rep 64:1419-26 (2012). Read more (PubMed: 23406752) »
  • Mathews JM  et al. Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro. Drug Metab Dispos 33:1555-63 (2005). Read more (PubMed: 16033948) »
  • Martin HB  et al. Kavain attenuates vascular contractility through inhibition of calcium channels. Planta Med 68:784-9 (2002). Read more (PubMed: 12357387) »
  • Walden J  et al. Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 21:697-706 (1997). Read more (PubMed: 9194150) »

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