Key features and details
- Rabbit polyclonal to KCC2
- Reacts with: Rat, Dog
- Isotype: IgG
Product nameAnti-KCC2 antibody
See all KCC2 primary antibodies
DescriptionRabbit polyclonal to KCC2
Species reactivityReacts with: Rat, Dog
Predicted to work with: a wide range of other species
N-terminal His-tag fusion protein corresponding to residues 932-1043 of rat K+/Cl- Cotransporter (KCC2).
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.184% Tris glycine, 30% Glycerol, 0.87% Sodium chloride
Concentration information loading...
PurityProtein A purified
FunctionMediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Tissue specificityBrain specific. Detected in neuronal cells.
Sequence similaritiesBelongs to the SLC12A transporter family.
- Information by UniProt
- Electroneutral potassium chloride cotransporter 2 antibody
- Electroneutral potassium-chloride cotransporter 2 antibody
- Erythroid K Cl cotransporter 2 antibody
ab49917 has been referenced in 10 publications.
- Venugopalan P et al. Physiologic maturation is both extrinsically and intrinsically regulated in progenitor-derived neurons. Sci Rep 10:2337 (2020). PubMed: 32047174
- Sears SMS et al. Decreased epileptogenesis in mice lacking the System xc- transporter occurs in association with a reduction in AMPA receptor subunit GluA1. Epilepsia Open 4:133-143 (2019). PubMed: 30868123
- Gogliotti RG et al. Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target. J Pharmacol Exp Ther 365:291-300 (2018). PubMed: 29523700
- Wang Y et al. Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. Neuron 95:92-105.e5 (2017). PubMed: 28648501
- Miceli S et al. Reduced Inhibition within Layer IV of Sert Knockout Rat Barrel Cortex is Associated with Faster Sensory Integration. Cereb Cortex 27:933-949 (2017). PubMed: 28158484
- Hu D et al. Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress. Sci Rep 7:11878 (2017). PubMed: 28928398
- Kuang Y et al. Low-frequency stimulation of the primary focus retards positive transfer of secondary focus. Sci Rep 7:345 (2017). PubMed: 28336934
- Yeo M et al. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proc Natl Acad Sci U S A 110:4315-20 (2013). ICC/IF ; Mouse . PubMed: 23440186
- Murguía-Castillo J et al. NKCC1 and KCC2 protein expression is sexually dimorphic in the hippocampus and entorhinal cortex of neonatal rats. Neurosci Lett 552:52-7 (2013). WB . PubMed: 23932891
- Wang Y et al. Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors. J Neurophysiol 108:2668-78 (2012). IHC ; Rat . PubMed: 22933718