Overview

  • Product name
    Anti-KCC4 antibody - N-terminal
    See all KCC4 primary antibodies
  • Description
    Rabbit polyclonal to KCC4 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human KCC4 aa 96-125 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9Y666

  • Positive control
    • HepG2 cell line lysates; Human heart tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab170623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 119 kDa.

Target

  • Function
    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification.
  • Tissue specificity
    Detected in muscle, brain, lung, heart and kidney.
  • Sequence similarities
    Belongs to the SLC12A transporter family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • D13Ertd261e antibody
    • Electroneutral potassium-chloride cotransporter 4 antibody
    • Furosemide sensitive KCl cotransporter 4 antibody
    • K Cl cotransporter KCC4 antibody
    • K-Cl cotransporter 4 antibody
    • Potassium/chloride transporter KCC4 antibody
    • S12A7_HUMAN antibody
    • SLC12A7 antibody
    • Solute carrier family 12 (potassium/chloride transporters), member 7 antibody
    • Solute carrier family 12 member 7 antibody
    • Solute carrier family 12, member 7 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling KCC4 with ab170623 at 1/10 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

  • Anti-KCC4 antibody - N-terminal (ab170623) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size: 119 kDa

References

ab170623 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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