• Product name

  • Description

    Rabbit polyclonal to KChIP2
  • Host species

  • Tested applications

    Suitable for: IHC-P, ICC, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Rabbit, Dog, Non human primates
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Human KChIP2 aa 6-24.


    (Peptide available as ab4991)


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Primary antibody notes

    Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP 1 expressed in the brain; KChIP 2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP 3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab3473 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
WB Use a concentration of 2 µg/ml.

By Western blot, this antibody detects ~33 and 26 kDa proteins representing KChIP2b and c, respectively, from rat ventricular myocyte whole cell lysate.


  • Function

    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart.
  • Tissue specificity

    Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
  • Sequence similarities

    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Post-translational

    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • Cellular localization

    Cell membrane and Cell membrane. Detected on lipid rafts (By similarity).
  • Information by UniProt
  • Database links

  • Form

    There are 9 isoforms produced by alternative splicing.
  • Alternative names

    • A type potassium channel modulatory protein 2 antibody
    • A-type potassium channel modulatory protein 2 antibody
    • Cardiac voltage gated potassium channel modulatory subunit antibody
    • Cardiac voltage-gated potassium channel modulatory subunit antibody
    • DKFZp566L1246 antibody
    • KChIP 2 antibody
    • KChIP2 antibody
    • KCIP2_HUMAN antibody
    • KCNIP 2 antibody
    • Kcnip2 antibody
    • Kv channel interacting protein 2 antibody
    • Kv channel-interacting protein 2 antibody
    • MGC17241 antibody
    • Potassium channel interacting protein 2 antibody
    • Potassium channel-interacting protein 2 antibody
    see all


This product has been referenced in:

  • Cho JH  et al. Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI Insight 3:N/A (2018). Read more (PubMed: 30282820) »
See 1 Publication for this product

Customer reviews and Q&As

Western blot
Dog Cell lysate - whole cell (heart)
Loading amount
40 µg
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5%

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Submitted Apr 20 2007

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