Key features and details
- Rabbit polyclonal to KCNA5/KV1-5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-KCNA5/KV1-5 antibody
See all KCNA5/KV1-5 primary antibodies
DescriptionRabbit polyclonal to KCNA5/KV1-5
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide within Human KCNA5/KV1-5 (C terminal). The exact sequence is proprietary.
Database link: P22460
- Endometrium tissue
This product was previously labelled as KCNA5
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab181798 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/1000.|
FunctionMediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
Tissue specificityPancreatic islets and insulinoma.
Involvement in diseaseDefects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Sequence similaritiesBelongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
DomainThe amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
modificationsSumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
- Information by UniProt
- ATFB7 antibody
- cardiac potassium channel antibody
- HCK1 antibody
ab181798 has been referenced in 3 publications.
- Zhang F et al. Association between connexin 40 and potassium voltage-gated channel subfamily A member 5 expression in the atrial myocytes of patients with atrial fibrillation. Exp Ther Med 14:5170-5176 (2017). WB ; Human . PubMed: 29201233
- Zhang S et al. Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K? channels. Mol Med Rep 13:3415-22 (2016). WB . PubMed: 26957114
- Wu J et al. Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells. Int J Mol Sci 16:26914-26 (2015). WB ; Human . PubMed: 26569226