Overview

  • Product name

  • Description

    Rabbit polyclonal to KCNA5/KV1-5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human KCNA5/KV1-5 (C terminal). The exact sequence is proprietary.
    Database link: P22460

  • Positive control

    • Endometrium tissue
  • General notes

     This product was previously labelled as KCNA5

     

Properties

Applications

Our Abpromise guarantee covers the use of ab181798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/1000 - 1/5000. Predicted molecular weight: 67 kDa.

Target

  • Function

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
  • Tissue specificity

    Pancreatic islets and insulinoma.
  • Involvement in disease

    Defects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • Sequence similarities

    Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
  • Domain

    The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications

    Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATFB7 antibody
    • cardiac potassium channel antibody
    • HCK1 antibody
    • HK2 antibody
    • HPCN1 antibody
    • insulinoma and islet potassium channel antibody
    • KCNA5 antibody
    • KCNA5_HUMAN antibody
    • KV1.5 antibody
    • PCN1 antibody
    • potassium channel 1 antibody
    • Potassium channel, insulinoma and islet cell antibody
    • Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody
    • Potassium voltage gated channel subfamily A member 5 antibody
    • Potassium voltage-gated channel subfamily A member 5 antibody
    • Voltage-gated potassium channel HK2 antibody
    • voltage-gated potassium channel protein Kv1.5 antibody
    • Voltage-gated potassium channel subunit Kv1.5 antibody
    see all

Images

  • Immunohistochemical analysis of Human endometrial tissue, staining KCNA5/KV1-5 with ab181798 at 1/100 dilution.

References

This product has been referenced in:

  • Zhang F  et al. Association between connexin 40 and potassium voltage-gated channel subfamily A member 5 expression in the atrial myocytes of patients with atrial fibrillation. Exp Ther Med 14:5170-5176 (2017). WB ; Human . Read more (PubMed: 29201233) »
  • Zhang S  et al. Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K? channels. Mol Med Rep 13:3415-22 (2016). WB . Read more (PubMed: 26957114) »
See all 3 Publications for this product

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