Anti-KCNC1 antibody (ab230686)
Key features and details
- Rabbit polyclonal to KCNC1
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-KCNC1 antibody
See all KCNC1 primary antibodies -
Description
Rabbit polyclonal to KCNC1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Rat, Human
Predicted to work with: Mouse, Rabbit, Cow -
Immunogen
Synthetic peptide corresponding to Human KCNC1 (internal sequence) conjugated to keyhole limpet haemocyanin.
Database link: P48547 -
Positive control
- WB: HepG2 whole cell lysate; rat brain whole cell lysate. IHC-P: Human cerebellum tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.01% Sodium azide
Constituents: PBS, 30% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab230686 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 58 kDa.
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IHC-P |
1/100.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 58 kDa. |
IHC-P
1/100. |
Target
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Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. -
Involvement in disease
Epilepsy, progressive myoclonic 7 -
Sequence similarities
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. -
Domain
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 3746 Human
- Entrez Gene: 16502 Mouse
- Entrez Gene: 25327 Rat
- Omim: 176258 Human
- SwissProt: P48547 Human
- SwissProt: P15388 Mouse
- SwissProt: P25122 Rat
- Unigene: 552896 Human
see all -
Alternative names
- C230009H10Rik antibody
- FLJ41162 antibody
- FLJ42249 antibody
see all
Images
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All lanes : Anti-KCNC1 antibody (ab230686) at 1/500 dilution
Lane 1 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
Lane 2 : Rat brain whole cell lysate
Developed using the ECL technique.
Predicted band size: 58 kDa -
Formalin-fixed, paraffin-embedded human cerebellum tissue stained for KCNC1 with ab230686 at 1/100 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab230686 has not yet been referenced specifically in any publications.