• Product name

  • Description

    Rabbit polyclonal to KCNC3
  • Host species

  • Tested applications

    Suitable for: ELISA, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 468-517 (YAERIGADPD DILGSNHTYF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM) of human KCNC3 (NP_004968).

  • Positive control

    • 293T cell lysate.


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Purified by peptide affinity chromatography method.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab83556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay, 1/62500.

WB Use a concentration of 1 µg/ml. Predicted molecular weight: 81 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function

    This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • Involvement in disease

    Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
  • Sequence similarities

    Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
  • Domain

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Kcnc3 antibody
    • KCNC3_HUMAN antibody
    • KSHIIID antibody
    • KV3.3 antibody
    • Potassium voltage gated channel Shaw related subfamily member 3 antibody
    • Potassium voltage gated channel subfamily C member 3 antibody
    • Potassium voltage-gated channel subfamily C member 3 antibody
    • SCA13 antibody
    • Shaw related subfamily, member 3 antibody
    • Shaw related voltage gated potassium channel protein 3 antibody
    • Spinocerebellar ataxia 13 antibody
    • Voltage gated potassium channel protein KV3.3 antibody
    • Voltage gated potassium channel subunit Kv3.3 antibody
    • Voltage-gated potassium channel subunit Kv3.3 antibody
    see all


  • Western blot analysis of Human fetal lung tissue lysate labeling KCNC3 with ab83556 at 1.0µg/ml.
  • Anti-KCNC3 antibody (ab83556) at 1 µg/ml + 293T cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 81 kDa
    Observed band size: 81 kDa

    Gel concentration 12%


This product has been referenced in:

  • Song MS  et al. Kv3.4 is modulated by HIF-1a to protect SH-SY5Y cells against oxidative stress-induced neural cell death. Sci Rep 7:2075 (2017). WB ; Human . Read more (PubMed: 28522852) »
  • Pawellek A  et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife 6:N/A (2017). Read more (PubMed: 28884683) »
See all 2 Publications for this product

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