• Product name

  • Description

    Rabbit polyclonal to KCNE1
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the N terminal domain of human KCNE1.

  • Positive control

    • This antibody gave a positive result when used in the following formaldehyde fixed cell lines: HepG2.



Our Abpromise guarantee covers the use of ab65795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 15 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/200.


  • Function

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
  • Tissue specificity

    Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.
  • Involvement in disease

    Jervell and Lange-Nielsen syndrome 2 (JLNS2) [MIM:612347]: An autosomal recessive disorder characterized by congenital deafness, prolongation of the QT interval, syncopal attacks due to ventricular arrhythmias, and a high risk of sudden death. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Long QT syndrome 5 (LQT5) [MIM:613695]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the potassium channel KCNE family.
  • Post-translational

    Phosphorylation inhibits the potassium current.
    N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Delayed rectifier potassium channel subunit IsK antibody
    • Human cardiac delayed rectifier potassium channel protein antibody
    • IKs producing slow voltage gated potassium channel subunit beta Mink antibody
    • IKs producing slow voltage-gated potassium channel subunit beta Mink antibody
    • ISK antibody
    • JLNS 2 antibody
    • JLNS antibody
    • JLNS2 antibody
    • KCNE 1 antibody
    • KCNE1 antibody
    • KCNE1_HUMAN antibody
    • LQT 5 antibody
    • LQT5 antibody
    • MGC33114 antibody
    • Minimal potassium channel antibody
    • MinK antibody
    • Potassium voltage gated channel Isk related family member 1 antibody
    • Potassium voltage gated channel Isk related subfamily member 1 antibody
    • Potassium voltage gated channel subfamily E member 1 antibody
    • Potassium voltage-gated channel subfamily E member 1 antibody
    see all


  • ICC/IF image of ab65795 stained HepG2 cells.  The cells were 4% formaldehyde fixed (10 min) and then incubated in 1% BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab65795 at 1/200 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 Goat anti-Rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.


This product has been referenced in:

  • Alexander J  et al. Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS One 13:e0190698 (2018). Read more (PubMed: 29470513) »
See 1 Publication for this product

Customer reviews and Q&As


Thank you for contacting us.

The blocking peptide for the rabbit polyclonal anti-KCNE1 is now available, the catalog reference number is ab151760 and the link to the datasheet is https://www.abcam.com/ab151760.

Unfortunately, the peptide used to raise the clone [S37A-10] is not commercially available.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

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