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    kcnn3sk3-antibody-ab220864.pdf

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Neuroscience Neurotransmission Receptors / Channels Potassium Channels
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Anti-KCNN3/SK3 antibody (ab220864)

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Immunocytochemistry/ Immunofluorescence - Anti-KCNN3/SK3 antibody (ab220864)

    Key features and details

    • Rabbit polyclonal to KCNN3/SK3
    • Suitable for: ICC/IF
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-KCNN3/SK3 antibody
      See all KCNN3/SK3 primary antibodies
    • Description

      Rabbit polyclonal to KCNN3/SK3
    • Host species

      Rabbit
    • Tested applications

      Suitable for: ICC/IFmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Pig
    • Immunogen

      Recombinant fragment corresponding to Human KCNN3/SK3 aa 202-267.
      Sequence:

      NLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHA GTTASSTTFPKANKRK


      Database link: Q9UGI6
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • PC-3 cells.
    • General notes

      Protein previously labeled as KCNN3.

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.20
      Preservative: 0.02% Sodium azide
      Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Neuroscience
      • Neurology process
      • Neural Signal Transduction

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    Our Abpromise guarantee covers the use of ab220864 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    ICC/IF Use a concentration of 0.25 - 2 µg/ml.

    Fixation/Permeabilization: PFA/Triton X-100.

    Target

    • Function

      Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
    • Sequence similarities

      Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q9UGI6 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 3782 Human
      • Entrez Gene: 140493 Mouse
      • Entrez Gene: 397045 Pig
      • Entrez Gene: 54263 Rat
      • Omim: 602983 Human
      • SwissProt: Q9UGI6 Human
      • SwissProt: P58391 Mouse
      • SwissProt: P58392 Pig
      • SwissProt: P70605 Rat
      • Unigene: 490765 Human
      • Unigene: 586534 Human
      • Unigene: 120250 Mouse
      • Unigene: 10840 Rat
      see all
    • Alternative names

      • hSK3 antibody
      • KCa2.3 antibody
      • Kcnn3 antibody
      • KCNN3_HUMAN antibody
      • Potassium calcium activated channel subfamily N member 3 antibody
      • Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3 antibody
      • Potassium channel, calcium activated, intermediate/small conductance, subfamily N, member 3 antibody
      • Potassium intermediate/small conductance calcium activated channel subfamily N member 3 antibody
      • SK3 antibody
      • SKCa 3 antibody
      • SKCa3 antibody
      • Small conductance calcium-activated potassium channel protein 3 antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-KCNN3/SK3 antibody (ab220864)
      Immunocytochemistry/ Immunofluorescence - Anti-KCNN3/SK3 antibody (ab220864)

      Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized PC-3 cells labeling KCNN3/SK3 with ab220864 at 4 μg/ml (green).

    Protocols

    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab220864? Please let us know so that we can cite the reference in this datasheet.

    ab220864 has not yet been referenced specifically in any publications.

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