Overview

  • Product name

    Anti-KCNN4 antibody - C-terminal
    See all KCNN4 primary antibodies
  • Description

    Rabbit polyclonal to KCNN4 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human KCNN4 (C terminal). The exact sequence is proprietary. Conjugated to a carrier protein.
    Database link: O15554

  • Positive control

    • WB: Jurkat membrane and whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab229593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.

Target

  • Function

    Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
  • Tissue specificity

    Widely expressed in non-excitable tissues.
  • Sequence similarities

    Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
  • Post-translational
    modifications

    Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • DHS2 antibody
    • hIKCa1 antibody
    • hKCa4 antibody
    • hSK4 antibody
    • IK antibody
    • IK1 antibody
    • IKCa1 antibody
    • Intermediate conductance calcium activated potassium channel protein 4 antibody
    • Intermediate conductance calcium-activated potassium channel protein 4 antibody
    • KCa3.1 antibody
    • KCa4 antibody
    • KCNN 4 antibody
    • Kcnn4 antibody
    • KCNN4_HUMAN antibody
    • Potassium calcium activated channel subfamily N member 4 antibody
    • Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4 antibody
    • Putative Gardos channel antibody
    • SK4 antibody
    • SKCa 4 antibody
    • SKCa4 antibody
    see all

Images

  • All lanes : Anti-KCNN4 antibody - C-terminal (ab229593) at 1/1000 dilution

    Lane 1 : Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell extract
    Lane 2 : Jurkat (Human T cell leukemia cell line from peripheral blood) membrane extract

    Lysates/proteins at 30 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 48 kDa



    10% SDS-PAGE gel.

References

ab229593 has not yet been referenced specifically in any publications.

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