Overview

  • Product name
  • Description
    Rabbit polyclonal to KCNT1/SLACK
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human KCNT1/SLACK aa 1035-1061. The exact sequence is proprietary.
    Database link: Q5JUK3

  • Positive control
    • Human brain tissue lysate; Human brain tissue.
  • General notes

     This product was previously labelled as KCNT1

     

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride

    .PBS without Mg2+ and Ca2+.
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab199654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 138 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro).
  • Tissue specificity
    Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.
  • Sequence similarities
    Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.
    Contains 1 RCK N-terminal domain.
  • Post-translational
    modifications
    Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA100C15.2 antibody
    • EIEE14 antibody
    • ENFL5 antibody
    • KCa4.1 antibody
    • KCNT1 antibody
    • KCNT1_HUMAN antibody
    • Potassium channel subfamily T member 1 antibody
    • Potassium channel, sodium activated subfamily T, member 1 antibody
    • Potassium channel, subfamily T, member 1 antibody
    • Sequence like a calcium-activated K+ channel antibody
    • SLACK antibody
    • Slo2.2 antibody
    see all

Images

  • Anti-KCNT1/SLACK antibody (ab199654) at 1/1000 dilution + Human brain tissue lysate at 35 µg

    Secondary
    Goat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

    Predicted band size: 138 kDa

  • Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling KCNT1/SLACK with ab199654 at 1/50 dilution.

References

ab199654 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab199654.
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