Overview

  • Product name

    Anti-KCTD11/REN antibody
  • Description

    Goat polyclonal to KCTD11/REN
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to Human KCTD11/REN aa 167-178 (internal sequence) (Cysteine residue).
    Sequence:

    PEVEYGRLGLQP


    Database link: NP_001002914.1

  • Positive control

    • HEK293 lysate overexpressing Human KCTD11/REN.
  • General notes

     This product was previously labelled as KCTD11

     

Properties

Applications

Our Abpromise guarantee covers the use of ab113423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 26 kDa). Primary incubation time: 1 hour.

Target

  • Relevance

    The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.
  • Database links

  • Alternative names

    • C 17 orf 36 antibody
    • C17orf36 antibody
    • MGC 129844 antibody
    • Potassium channel tetramerisation domain containing 11 antibody
    • REN antibody
    • Retinoic acid EGF NGF induced gene protein antibody
    see all

Images

  • Lane 1 : Anti-KCTD11/REN antibody (ab113423) at 1 µg/ml
    Lane 2 : Anti-KCTD11/REN antibody (ab113423) at 1 mg/ml
    Lane 3 : anti-DYKDDDDK Tag at 1/5000 dilution

    Lanes 1 & 3 : HEK293 lysate, (in RIPA buffer) overexpressing Human KCTD11/REN with DYKDDDDK tag at 10 µg
    Lane 2 : HEK293 lysate, Mock-transfected

    Developed using the ECL technique.

    Predicted band size: 26 kDa

References

This product has been referenced in:

  • Tong R  et al. KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling. Oncotarget 8:37717-37729 (2017). Read more (PubMed: 28465479) »
See 1 Publication for this product

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