Overview

  • Product name

    KD5170, HDAC inhibitor
  • Description

    Potent, non-selective HDAC inhibitor. Antiproliferative agent.
  • Biological description

    Potent, non-selective HDAC inhibitor (IC50 values are 14, 20, 26 and 75 nM for HDAC6, 1, 4, and 3, respectively and 2 μM for HDAC2). Antiproliferative agent. Induces oxidative stress and oxidative DNA damage. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 96%
  • CAS Number

    940943-37-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    S-[2-[6-[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonylamino]-3-pyridinyl]-2-oxoethyl] ethanethioic acid ester
  • Molecular weight

    451.55
  • Molecular formula

    C20H25N3O5S2
  • PubChem identifier

    17754557
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in 1eq. HCl to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hassig CA  et al. KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 7:1054-65 (2008). Read more (PubMed: 18483295) »
  • Feng R  et al. KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling. Mol Cancer Ther 7:1494-505 (2008). Read more (PubMed: 18566220) »
  • Payne JE  et al. Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor. Bioorg Med Chem Lett 18:6093-6 (2008). Read more (PubMed: 18954983) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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