Key features and details
- Mouse monoclonal [2E7] to KDEL Receptor
- Suitable for: IHC-P
- Reacts with: Drosophila melanogaster, Plants, Wheat
- Isotype: IgG2b
Product nameAnti-KDEL Receptor antibody [2E7]
See all KDEL Receptor primary antibodies
DescriptionMouse monoclonal [2E7] to KDEL Receptor
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Drosophila melanogaster, Plants, Wheat, Other species
Synthetic peptide corresponding to Saccharomyces cerevisiae KDEL Receptor (C terminal).
- IHC-P: Human kidney tissue.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol, PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab96720 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration.|
RelevanceRetention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
Cellular localizationEndoplasmic reticulum
- ER lumen protein retaining receptor 1 antibody
- ERD 2 antibody
- ERD2 antibody
ab96720 has not yet been referenced specifically in any publications.