Overview

  • Product name

    Anti-KDEL Receptor antibody [2E7]
    See all KDEL Receptor primary antibodies
  • Description

    Mouse monoclonal [2E7] to KDEL Receptor
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Drosophila melanogaster, Plants, Wheat, Other species
  • Immunogen

    Synthetic peptide corresponding to Saccharomyces cerevisiae KDEL Receptor (C terminal).

  • Positive control

    • IHC-P: Human kidney tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.40
    Preservative: 0.09% Sodium azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    2E7
  • Isotype

    IgG2b
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/1000 - 1/2000. Predicted molecular weight: 78 kDa.
ICC/IF 1/50 - 1/100.

Target

  • Relevance

    Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
  • Cellular localization

    Endoplasmic reticulum
  • Alternative names

    • ER lumen protein retaining receptor 1 antibody
    • ERD 2 antibody
    • ERD2 antibody
    • ERD2.1 antibody
    • ERD21 antibody
    • HDEL antibody
    • KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 1 antibody
    • KDEL (Lys-Asp-Glu-Leu) 72 kD endoplasmic reticulum protein retention receptor 1 antibody
    • KDEL endoplasmic reticulum protein retention receptor 1 antibody
    • KDEL R1 antibody
    • KDEL receptor 1 antibody
    • KDELR 1 antibody
    • KDELR1 antibody
    • PM 23 antibody
    • PM23 antibody
    • Putative MAPK activating protein PM23 antibody
    see all

Images

  • ab96720 at 1/20,000 dilution staining KDEL Receptor in a human kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Secondary antibody was biotinylated Goat anti-mouse. Picture at 400X magnification.

References

ab96720 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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