Anti-KDM1 / LSD1 antibody - ChIP Grade (ab17721)

Knockout Tested Rabbit polyclonal KDM1 / LSD1 antibody. Validated in WB, IP, IHC, ChIP, ICC/IF and tested in Mouse, Human, Pig. Cited in 133 publication(s). Independently reviewed in 21 review(s).

Publishing research using ab17721? Please let us know so that we can cite the reference in this datasheet.

ab17721 has been referenced in 136 publications.

  • Andresini O  et al. The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region. Epigenetics Chromatin 12:8 (2019). PubMed: 30651140
  • Lee C  et al. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun 10:332 (2019). PubMed: 30659187
  • Takase R  et al. Lysine-specific demethylase-2 is distinctively involved in brown and beige adipogenic differentiation. FASEB J 33:5300-5311 (2019). PubMed: 30681884
  • Wang J  et al. Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock. Proc Natl Acad Sci U S A 115:E244-E252 (2018). PubMed: 29263096
  • Wu J  et al. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol N/A:N/A (2018). PubMed: 30582981
  • Yamamoto R  et al. Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells. Oncotarget 9:21007-21021 (2018). PubMed: 29765516
  • Anan K  et al. LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation. Nucleic Acids Res 46:5441-5454 (2018). PubMed: 29618057
  • Sheng W  et al. LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell 174:549-563.e19 (2018). PubMed: 29937226
  • Boulding T  et al. LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Sci Rep 8:73 (2018). PubMed: 29311580
  • Cao K  et al. An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells. Sci Adv 4:eaap8747 (2018). PubMed: 29404406
  • Kalin JH  et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun 9:53 (2018). WB . PubMed: 29302039
  • Patel D  et al. The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS One 13:e0191689 (2018). PubMed: 29370269
  • Sun J  et al. Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res 6:14 (2018). PubMed: 29707403
  • Monaghan CE  et al. REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. Proc Natl Acad Sci U S A 114:E406-E415 (2017). IHC ; Mouse . PubMed: 28049845
  • Jang MJ  et al. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPAR? and inhibit adipogenesis. Cell Death Dis 8:3201 (2017). PubMed: 29233982
  • Myrick DA  et al. KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice. PLoS One 12:e0177473 (2017). PubMed: 28498828
  • Hirano K & Namihira M FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1. FEBS Open Bio 7:1932-1942 (2017). PubMed: 29226080
  • Carnesecchi J  et al. ERRa protein is stabilized by LSD1 in a demethylation-independent manner. PLoS One 12:e0188871 (2017). PubMed: 29190800
  • Kuvardina ON  et al. Hematopoietic transcription factors and differential cofactor binding regulatePRKACBisoform expression. Oncotarget 8:71685-71698 (2017). PubMed: 29069738
  • Carnesecchi J  et al. ERRa induces H3K9 demethylation by LSD1 to promote cell invasion. Proc Natl Acad Sci U S A 114:3909-3914 (2017). PubMed: 28348226
  • Saha D  et al. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. J Biol Chem 292:15205-15215 (2017). PubMed: 28717007
  • Li L  et al. ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nat Commun 8:691 (2017). PubMed: 28947780
  • Goossens S  et al. Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia. Blood 129:981-990 (2017). PubMed: 28069602
  • Sharma R  et al. Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice. Elife 6:N/A (2017). PubMed: 28262096
  • Christopher MA  et al. LSD1 protects against hippocampal and cortical neurodegeneration. Nat Commun 8:805 (2017). IHC . PubMed: 28993646
  • Gigante CM  et al. Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation. Nat Commun 8:15098 (2017). IHC ; Mouse . PubMed: 28425486
  • Ray SK  et al. Oligomeric form of C-terminal-binding protein coactivates NeuroD1-mediated transcription. FEBS Lett 591:205-212 (2017). PubMed: 27880001
  • Kulej K  et al. Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) Infection. Mol Cell Proteomics 16:S92-S107 (2017). PubMed: 28179408
  • Byun S  et al. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J 36:1755-1769 (2017). PubMed: 28446510
  • Muralidharan B  et al. LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J Neurosci 37:194-203 (2017). IP, CHIPseq ; Mouse . PubMed: 28053041
  • Ancelin K  et al. Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife 5:N/A (2016). IF . PubMed: 26836306
  • Ma L  et al. miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells. Cancer Med 5:684-92 (2016). WB . PubMed: 26833707
  • Alarcon V  et al. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state. Sci Rep 6:25901 (2016). PubMed: 27174370
  • Wasson JA  et al. Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally. Elife 5:N/A (2016). IF, IHC . PubMed: 26814574
  • Petell CJ  et al. An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation. Nucleic Acids Res 44:7605-17 (2016). WB, IP ; Mouse . PubMed: 27179026
  • Joo YA  et al. Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid. Biomol Ther (Seoul) 24:529-35 (2016). PubMed: 27169822
  • Zeng X  et al. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev 30:1822-36 (2016). PubMed: 27566776
  • Vasconcelos FF  et al. MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis. Cell Rep 17:469-483 (2016). ChIP, CHIPseq . PubMed: 27705795
  • Wang Y  et al. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun 7:10481 (2016). ChIP ; Mouse . PubMed: 26795843
  • Singh D  et al. Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1. PLoS One 11:e0164506 (2016). ChIP ; Mouse . PubMed: 27768697
  • Sun H  et al. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Sci Rep 6:30903 (2016). WB . PubMed: 27481483
  • Hirano K & Namihira M LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL. Stem Cells 34:1872-82 (2016). PubMed: 27018646
  • Brenner C  et al. The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent. Oncotarget 7:58939-58952 (2016). PubMed: 27449289
  • Zhou A  et al. Nuclear GSK3ß promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol 18:954-966 (2016). PubMed: 27501329
  • Chen Y  et al. Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling. Cell Chem Biol 23:1228-1240 (2016). PubMed: 27642069
  • Sengupta A  et al. Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b. J Cell Sci 129:145-54 (2016). PubMed: 26567214
  • Schmitt AM  et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet 48:1370-1376 (2016). PubMed: 27668660
  • Zhang ZZ  et al. Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes. Sci Rep 6:27435 (2016). WB . PubMed: 27272474
  • Eguizabal C  et al. Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming. Stem Cells 34:2418-28 (2016). ICC/IF . PubMed: 27300161
  • Dai Y  et al. Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms. Blood Cells Mol Dis 56:62-9 (2016). WB, ChIP ; Human . PubMed: 26603726
  • Guo Y  et al. Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther 9:3153-62 (2015). PubMed: 26124638
  • Piao L  et al. SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells. Oncotarget 6:16939-50 (2015). WB . PubMed: 26183527
  • Stadhouders R  et al. Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Nat Commun 6:8893 (2015). PubMed: 26593974
  • Latos PA  et al. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun 6:7776 (2015). WB . PubMed: 26206133
  • Ranzani V  et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol 16:318-325 (2015). ChIP . PubMed: 25621826
  • Sakamoto A  et al. Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells. Cancer Res 75:1445-56 (2015). PubMed: 25649769
  • Schooley A  et al. The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis. J Cell Sci 128:3466-77 (2015). PubMed: 26224877
  • Miles WO  et al. The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol 35:4199-211 (2015). PubMed: 26438601
  • Amente S  et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget 6:14572-83 (2015). ChIP . PubMed: 26062444
  • Kim TW  et al. Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency. Stem Cells 33:2442-55 (2015). PubMed: 25944056
  • Akiyama T  et al. Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells. DNA Res 22:307-18 (2015). PubMed: 26324425
  • Grandy RA  et al. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Mol Cell Biol 36:615-27 (2015). WB ; Human . PubMed: 26644406
  • Sáez JE  et al. Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. PLoS One 10:e0131760 (2015). PubMed: 26111147
  • Joiner AM  et al. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci 35:13761-72 (2015). IHC ; Mouse . PubMed: 26446227
  • Aguilo F  et al. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Cell Stem Cell 17:689-704 (2015). PubMed: 26526723
  • Laurent B  et al. A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation. Mol Cell 57:957-70 (2015). PubMed: 25684206
  • Kim YC  et al. Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2. Genome Biol 16:268 (2015). PubMed: 26634251
  • Kim YC  et al. Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology 62:220-31 (2015). Mouse . PubMed: 25545350
  • Cleys ER  et al. Androgen receptor and histone lysine demethylases in ovine placenta. PLoS One 10:e0117472 (2015). IP, ChIP ; Sheep . PubMed: 25675430
  • Mino K  et al. Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2). Biosci Biotechnol Biochem 78:1010-7 (2014). PubMed: 25036127
  • Barrios ÁP  et al. Differential properties of transcriptional complexes formed by the CoREST family. Mol Cell Biol 34:2760-70 (2014). PubMed: 24820421
  • Ferrari-Amorotti G  et al. Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity. Neoplasia 16:1047-58 (2014). PubMed: 25499218
  • Su CH  et al. An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells. Nucleic Acids Res 42:3073-88 (2014). ChIP ; Human . PubMed: 24371278
  • Yin F  et al. LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16. Mol Cell Biol 34:158-79 (2014). PubMed: 24190971
  • Seki M  et al. A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS One 9:e95374 (2014). CHIPseq ; Mouse . PubMed: 24752154
  • Upadhyay G  et al. Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc Natl Acad Sci U S A 111:8071-6 (2014). PubMed: 24843136
  • Yokoyama A  et al. Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. J Biol Chem 289:18152-18162 (2014). WB, ChIP . PubMed: 24828497
  • Ray SK  et al. CtBP and Associated LSD1 Are Required for Transcriptional Activation by NeuroD1 in Gastrointestinal Endocrine Cells. Mol Cell Biol 34:2308-2317 (2014). PubMed: 24732800
  • Liu D & Zempleni J Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells. J Nutr 144:997-1001 (2014). Human . PubMed: 24744315
  • Derr RS  et al. High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. BMC Cancer 14:604 (2014). IHC-P ; Human . PubMed: 25139823
  • Liu D & Zempleni J Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells. Genes Nutr 9:422 (2014). WB ; Human . PubMed: 25103574
  • Ketscher A  et al. LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Oncogenesis 3:e120 (2014). CHIPseq ; Human . PubMed: 25285406
  • Porro A  et al. TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep 6:765-76 (2014). PubMed: 24529708
  • Li L  et al. Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. Sci Signal 7:ra47 (2014). PubMed: 24847116
  • Sankar S  et al. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res 20:4584-97 (2014). PubMed: 24963049
  • Ouyang H  et al. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One 8:e62192 (2013). ChIP . PubMed: 23626788
  • Miao F  et al. RNA-sequencing analysis of high glucose-treated monocytes reveals novel transcriptome signatures and associated epigenetic profiles. Physiol Genomics 45:287-99 (2013). ChIP ; Human . PubMed: 23386205
  • Ferrari-Amorotti G  et al. Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion. Cancer Res 73:235-45 (2013). PubMed: 23054398
  • Shi L  et al. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med 19:291-4 (2013). PubMed: 23416702
  • Lin S  et al. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem 288:6238-47 (2013). PubMed: 23349461
  • Kerenyi MA  et al. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2:e00633 (2013). CHIPseq ; Mouse . PubMed: 23795291
  • Yakulov T  et al. Wnt3a-dependent and -independent protein interaction networks of chromatin-bound ß-catenin in mouse embryonic stem cells. Mol Cell Proteomics 12:1980-94 (2013). PubMed: 23592333
  • Pan D  et al. Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation. PLoS One 8:e66294 (2013). WB ; Mouse, Human . PubMed: 23755305
  • Maksakova IA  et al. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells. Epigenetics Chromatin 6:15 (2013). WB . PubMed: 23735015
  • Li L  et al. Targeted disruption of hotair leads to homeotic transformation and gene derepression. Cell Rep 5:3-12 (2013). ChIP ; Mouse . PubMed: 24075995
  • Layman WS  et al. Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. Hear Res 304:167-78 (2013). IHC-Fr ; Mouse . PubMed: 23911933
  • Zhang X  et al. Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells. Cell Rep 5:445-57 (2013). ChIP ; Human . PubMed: 24139802
  • Bao J  et al. Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. Biol Reprod 89:107 (2013). IP ; Mouse . PubMed: 24048575
  • Konovalov S & Garcia-Bassets I Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res 6:75 (2013). WB . PubMed: 24165091
  • Xu J  et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A 110:6518-23 (2013). ChIP ; Human . PubMed: 23576758
  • Clements EG  et al. DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. Nucleic Acids Res 40:4334-46 (2012). IP . PubMed: 22278882
  • Auriemma LB  et al. Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene. Epigenetics Chromatin 5:2 (2012). PubMed: 22240255
  • Williams JS  et al. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens 25:812-7 (2012). PubMed: 22534796
  • Whyte WA  et al. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature 482:221-5 (2012). PubMed: 22297846
  • Hisada K  et al. RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells. Mol Cell Biol 32:1139-49 (2012). WB ; Mouse . PubMed: 22269950
  • Le Douce V  et al. LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res 40:1904-15 (2012). WB, ICC/IF, ChIP . PubMed: 22067449
  • Pollock JA  et al. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERa-dependent and -independent manners. ACS Chem Biol 7:1221-31 (2012). PubMed: 22533360
  • Okabe J  et al. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circ Res 110:1067-76 (2012). WB . PubMed: 22403242
  • McDonald OG  et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol 18:867-74 (2011). PubMed: 21725293
  • Hung T  et al. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 43:621-9 (2011). PubMed: 21642992
  • Macfarlan TS  et al. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25:594-607 (2011). PubMed: 21357675
  • Cui S  et al. Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic {beta}-Type Globin Promoters in Differentiated Adult Erythroid Cells. Mol Cell Biol 31:3298-311 (2011). WB, ChIP ; Mouse . PubMed: 21670149
  • Wu CY  et al. Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function. Int J Cancer : (2011). PubMed: 22052438
  • Esteghamat F  et al. The DNA binding factor Hmg20b is a repressor of erythroid differentiation. Haematologica 96:1252-60 (2011). PubMed: 21606163
  • Wang Q  et al. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res 21:1424-35 (2011). WB ; Mouse . PubMed: 21727907
  • Lee SW  et al. ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem 285:18-29 (2010). WB ; Human . PubMed: 19880879
  • Anguita E  et al. GFI1B controls its own expression binding to multiple sites. Haematologica 95:36-46 (2010). PubMed: 19773260
  • van den Berg DL  et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6:369-81 (2010). PubMed: 20362541
  • Lin Y  et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J : (2010). IHC-P ; Human . PubMed: 20389281
  • Rai K  et al. DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC. Cell 142:930-42 (2010). ChIP ; Human . PubMed: 20850014
  • Choi J  et al. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun 401:327-32 (2010). WB, ICC/IF, IHC-P, ChIP, IP ; Mouse . PubMed: 20833138
  • Laurent B  et al. Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells. Stem Cells 27:2153-62 (2009). WB, ChIP ; Human . PubMed: 19522008
  • Saramäki A  et al. Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1{alpha},25-Dihydroxyvitamin D3. J Biol Chem 284:8073-82 (2009). ChIP ; Human . PubMed: 19122196
  • Zhu J  et al. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med 206:329-41 (2009). ChIP ; Mouse . PubMed: 19188499
  • Gu H & Roizman B Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol 83:4376-85 (2009). WB, ICC/IF, IP ; Human . PubMed: 19193804
  • Aslan JE  et al. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Mol Cell 34:497-509 (2009). ChIP ; Human . PubMed: 19481529
  • Turunen MP  et al. Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 105:604-9 (2009). ChIP . PubMed: 19696410
  • McColl G  et al. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem 283:350-7 (2008). WB ; Human . PubMed: 17959600
  • Seneda MM  et al. Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary. Reproduction 135:829-38 (2008). IHC-P ; Pig . PubMed: 18502896
  • Tsai WW  et al. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol 28:5139-46 (2008). ChIP, IP ; Human, Mouse . PubMed: 18573881
  • Ekici M  et al. Transcription of Genes Encoding Synaptic Vesicle Proteins in Human Neural Stem Cells: CHROMATIN ACCESSIBILITY, HISTONE METHYLATION PATTERN, AND THE ESSENTIAL ROLE OF REST. J Biol Chem 283:9257-68 (2008). PubMed: 18234667
  • Godmann M  et al. Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod 77:754-64 (2007). IHC-P ; Mouse . PubMed: 17634443
  • Scoumanne A & Chen X The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J Biol Chem 282:15471-5 (2007). PubMed: 17409384
  • Szewczuk LM  et al. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry 46:6892-902 (2007). PubMed: 17511474
  • Sánchez C  et al. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 6:820-34 (2007). PubMed: 17296600
  • Forneris F  et al. A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1. J Biol Chem 281:35289-95 (2006). PubMed: 16987819

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