Overview

  • Product name

    Anti-KDM4C / GASC1 / JMJD2C antibody
    See all KDM4C / GASC1 / JMJD2C primary antibodies
  • Description

    Rabbit polyclonal to KDM4C / GASC1 / JMJD2C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human KDM4C/ GASC1/ JMJD2C (internal sequence). The exact sequence is proprietary.
    Database link: Q9H3R0

  • Positive control

    • WB: HeLa and U-87 MG whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab227866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 120 kDa.

Target

  • Function

    Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • Tissue specificity

    Overexpressed in several esophageal squamous cell carcinomas (ESCs).
  • Sequence similarities

    Belongs to the JHDM3 histone demethylase family.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
    Contains 2 Tudor domains.
  • Domain

    The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • bA146B14.1 antibody
    • GASC 1 protein antibody
    • GASC-1 protein antibody
    • GASC1 antibody
    • Gene amplified in squamous cell carcinoma 1 protein antibody
    • JHDM3C antibody
    • JmjC domain containing histone demethylation protein 3C antibody
    • JmjC domain-containing histone demethylation protein 3C antibody
    • JMJD2C antibody
    • Jumonji domain containing 2C antibody
    • Jumonji domain containing protein 2C antibody
    • Jumonji domain-containing protein 2C antibody
    • Kdm4c antibody
    • KDM4C_HUMAN antibody
    • Lysine (K) specific demethylase 4C antibody
    • Lysine demethylase 4C antibody
    • Lysine-specific demethylase 4C antibody
    • TDRD14C antibody
    • Tudor domain containing 14C antibody
    see all

Images

  • Anti-KDM4C / GASC1 / JMJD2C antibody (ab227866) at 1/500 dilution + HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract at 30 µg

    Predicted band size: 120 kDa



    7.5% SDS-PAGE gel.

  • Anti-KDM4C / GASC1 / JMJD2C antibody (ab227866) at 1/500 dilution + U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract at 30 µg

    Predicted band size: 120 kDa



    7.5% SDS-PAGE gel.

References

ab227866 has not yet been referenced specifically in any publications.

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