Anti-KDM5B / PLU1 / Jarid1B antibody (ab211366)

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Overview

  • Product name

    Anti-KDM5B / PLU1 / Jarid1B antibody
    See all KDM5B / PLU1 / Jarid1B primary antibodies

  • Description

    Rabbit polyclonal to KDM5B / PLU1 / Jarid1B

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Recombinant fragment corresponding to Human KDM5B/ PLU1/ Jarid1B aa 1401-1481.
    Sequence:

    DGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFK LERERSYELVRSAETHSLPSDTSYSEQEDSE


    Database link: Q9UGL1

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • Human prostate tissue; KDM5B / PLU1 / Jarid1B over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab211366 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

  • Tissue specificity

    Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).

  • Sequence similarities

    Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 3 PHD-type zinc fingers.

  • Domain

    Both the JmjC domain and the JmjN domain are required for enzymatic activity.
    The 2 first PHD-type zinc finger domains are required for transcription repression activity.

  • Cellular localization

    Nucleus.
  • Information by UniProt

  • Database links

    • Alternative names

      • Cancer/testis antigen 31 antibody
      • CT31 antibody
      • Histone demethylase JARID1B antibody
      • JARID1B antibody
      • Jumonji AT rich interactive domain 1B antibody
      • Jumonji/ARID domain-containing protein 1B antibody
      • Kdm5b antibody
      • KDM5B_HUMAN antibody
      • Lysine (K) specific demethylase 5B antibody
      • Lysine demethylase 5B antibody
      • Lysine specific demethylase 5B antibody
      • Lysine-specific demethylase 5B antibody
      • PLU-1 antibody
      • PLU1 antibody
      • PPP1R98 antibody
      • Protein phosphatase 1 regulatory subunit 98 antibody
      • PUT1 antibody
      • putative DNA/chromatin binding motif antibody
      • RBBP2H1A antibody
      • RBP2 like antibody
      • RBP2-H1 antibody
      • Retinoblastoma-binding protein 2 homolog 1 antibody
      • Retinoblastoma-binding protein 2 homolog 1A antibody
      see all

    References

    ab211366 has not yet been referenced specifically in any publications.

    Publishing research using ab211366? Please let us know so that we can cite the reference in this datasheet.

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