Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab155681)

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Western blot - Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab155681)

    Key features and details

    • Rabbit polyclonal to KDM5C / Jarid1C / SMCX - N-terminal
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal
      See all KDM5C / Jarid1C / SMCX primary antibodies

    • Description

      Rabbit polyclonal to KDM5C / Jarid1C / SMCX - N-terminal

    • Host species

      Rabbit

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Cow, Dog

    • Immunogen

      Recombinant fragment corresponding to Human KDM5C/ Jarid1C/ SMCX aa 10-291 (N terminal).
      Database link: P41229

    • Positive control

      • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji whole cell lysates.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab155681 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 175 kDa.
    Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 175 kDa.

    Target

    • Function

      Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.

    • Tissue specificity

      Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.

    • Involvement in disease

      Defects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related (MRXSJ) [MIM:300534]. MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.

    • Sequence similarities

      Belongs to the JARID1 histone demethylase family.
      Contains 1 ARID domain.
      Contains 1 JmjC domain.
      Contains 1 JmjN domain.
      Contains 2 PHD-type zinc fingers.

    • Domain

      The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.
      Both the JmjC domain and the JmjN domain are required for enzymatic activity.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • DXS1272E antibody
      • Histone demethylase JARID1C antibody
      • JARID1C antibody
      • JmjC domain containing protein SMCX antibody
      • Jumonji AT rich interactive domain 1C antibody
      • Jumonji, AT rich interactive domain 1C (RBP2 like) antibody
      • Jumonji/ARID domain-containing protein 1C antibody
      • KDM5C antibody
      • KDM5C_HUMAN antibody
      • Lysine (K) specific demethylase 5C antibody
      • Lysine-specific demethylase 5C antibody
      • MRX13 antibody
      • MRXJ antibody
      • MRXSCJ antibody
      • MRXSJ antibody
      • Protein SmcX antibody
      • Protein Xe169 antibody
      • rbp2 like protein antibody
      • Selected cDNA on X antibody
      • SMCX antibody
      • Smcx homolog X chromosome antibody
      • SmcX protein antibody
      • Smcy homolog X linked antibody
      • XE169 antibody
      • Xe169 protein antibody
      see all

    Images

    • Western blot - Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab155681)
      Western blot - Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab155681)
      All lanes : Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab155681) at 1/1000 dilution

      Lane 1 : A431 whole cell lysate
      Lane 2 : HeLa whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 175 kDa



      5% SDS PAGE

    References (0)

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    ab155681 has not yet been referenced specifically in any publications.

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