Overview

  • Product name

    Anti-KDM5D / Jarid1D / SMCY antibody - C-terminal
  • Description

    Rabbit polyclonal to KDM5D / Jarid1D / SMCY - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide within Human KDM5D/ Jarid1D/ SMCY (C terminal). The exact sequence is proprietary. Conjugated to a carrier protein.
    Database link: Q9BY66

  • Positive control

    • WB: Jurkat whole cell and nuclear extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab227728 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 174 kDa.

Target

  • Function

    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.
  • Sequence similarities

    Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
  • Domain

    The JmjC domain is required for enzymatic activity.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • H-Y antibody
    • Histocompatibility Y antigen antibody
    • Histone demethylase JARID1D antibody
    • HY antibody
    • HYA antibody
    • JAD1D antibody
    • Jumonji AT rich interactive domain 1D (RBP2 like) antibody
    • Jumonji/ARID domain-containing protein 1D antibody
    • KDM5D antibody
    • KDM5D_HUMAN antibody
    • KIAA0234 antibody
    • Lysine (K) specific demethylase 5D antibody
    • Lysine demethylase 5D antibody
    • Lysine-specific demethylase 5D antibody
    • Protein SmcY antibody
    • Selected mouse cDNA on Y human homolog of antibody
    • SMC homolog Y chromosome antibody
    • Smcy homolog Y linked antibody
    see all

Images

  • All lanes : Anti-KDM5D / Jarid1D / SMCY antibody - C-terminal (ab227728) at 1/1000 dilution

    Lane 1 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell extract
    Lane 2 : Jurkat nuclear extract

    Lysates/proteins at 30 µg per lane.

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 174 kDa



    5% SDS-PAGE

References

ab227728 has not yet been referenced specifically in any publications.

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