Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Belongs to the UTX family. Contains 1 JmjC domain.
Western blot - Anti-KDM6B / JMJD3 antibody - C-terminal (ab154126)
Anti-KDM6B/JMJD3 antibody - C-terminal (ab154126) detects JMJD3 protein by western blot analysis. A. 30 µg 293T whole cell lysate/extract B. 30 µg A375 whole cell lysate/extract 5% SDS-PAGE Anti-KDM6B/JMJD3 antibody - C-terminal (ab154126) dilution: 1:1000 An HRP-conjugated anti-rabbit IgG secondary antibody was used to detect the primary antibody.