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Rabbit polyclonal to Keap1
Predicted to work with:
Sheep, Guinea pig, Pig, a wide range of other species
Synthetic peptide within Human Keap1 (C terminal). The exact sequence is proprietary.
Database link: Q14145
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Constituents: 1.21% Tris, 0.75% Glycine
Concentration information loading...
Protein A purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/2000. Predicted molecular weight: 70 kDa.
1/200 - 1/1000.
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Broadly expressed, with highest levels in skeletal muscle.
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.
The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
Ubiquitinated and subject to proteasomal degradation.
Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus.
Information by UniProt
Cytosolic inhibitor of Nrf2 antibody
INrf 2 antibody
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