Ketanserin, 5-HT2A/1D receptor antagonist (ab143210)

Overview

  • Product name

    Ketanserin, 5-HT2A/1D receptor antagonist
  • Description

    Potent, selective 5-HT2A/1D receptor antagonist
  • Biological description

    Potent, selective 5-HT2A/1D receptor antagonist (Ki values are 3-15 nM and 24-27 nM respectively). Orally active.
  • Purity

    > 97%
  • CAS Number

    74050-98-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
  • Molecular weight

    395.43
  • Molecular formula

    C22H22FN3O3
  • PubChem identifier

    3822
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Wurch T  et al. Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding. Mol Pharmacol 54:1088-96 (1998). Read more (PubMed: 9855638) »
  • Oliva D  et al. Non-serotonergic 3H-ketanserin binding sites in human platelets: characteristics and interaction with calcium antagonists. Pharmacol Res 26:187-99 (1992). Read more (PubMed: 1409259) »
  • Persson B  et al. Clinical pharmacokinetics of ketanserin. Clin Pharmacokinet 20:263-79 (1991). Read more (PubMed: 2036747) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143210.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up