Overview

  • Product name

    Ketoconazole, cytochrome P450 inhibitor
  • Description

    Potent cytochrome P450 inhibitor. Antifungal agent.
  • Biological description

    Potent cytochrome P450 inhibitor (Ki values are 26.7 and 109 nM at CYP3A4 and CYP3A5, respectively). Antifungal agent. Additionally, shows activity at human androgen receptors.
  • Purity

    > 99%
  • CAS Number

    65277-42-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Shah SS  et al. Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. J Vet Med Sci 71:1151-9 (2009). Read more (PubMed: 19801894) »
  • Gibbs MA  et al. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 27:180-7 (1999). Read more (PubMed: 9929500) »
  • Eil C Ketoconazole binds to the human androgen receptor. Horm Metab Res 24:367-70 (1992). Read more (PubMed: 1526623) »
See 1 Publication for this product

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