Overview

  • Product name

    Ketorolac tromethamine, COX-1 inhibitor
  • Description

    Selective COX-1 inhibitor
  • Biological description

    Selective COX-1 inhibitor. Inhibits prolieration and induces cell cycle arrest at G0/G1 in vitro. Anti-inflammatory agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    74103-07-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • Molecular weight

    376.40
  • Molecular formula

    C19H24N2O6
  • PubChem identifier

    84003
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chang JK  et al. Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology 258:148-56 (2009). Read more (PubMed: 19428934) »
  • Wallace JL  et al. NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119:706-14 (2000). Read more (PubMed: 10982765) »
  • Jett MF  et al. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 288:1288-97 (1999). Read more (PubMed: 10027870) »

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