• Product name
  • Description
    Rabbit polyclonal to Kidins220
  • Host species
  • Specificity
    ab34790 recognises Kidins220 (ARMS).
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 1747-1762 of Human Kidins220



Our Abpromise guarantee covers the use of ab34790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 220 kDa.
ICC/IF Use a concentration of 1 µg/ml.


  • Function
    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • Tissue specificity
    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • Sequence similarities
    Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • Domain
    The transmembrane domain mediates interaction with NTRK1.
  • Post-translational
    Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all


  • ICC/IF image of ab34790 stained PC12 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab34790, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.


This product has been referenced in:
  • Nahorski MS  et al. Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. Sci Rep 8:2340 (2018). Read more (PubMed: 29402896) »
  • Eisenhardt AE  et al. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget 7:26628-52 (2016). Read more (PubMed: 27034005) »
See all 6 Publications for this product

Customer reviews and Q&As


Thank you for contacting us. I am sorry we are unable to provide western blot images for anti Borrelia antibodies. I would suggest checking the Swissprot website for checking the molecular weight of unprocessed protein. http://www.uniprot.org/uniprot/?query=Borrelia+burgdorferi&offset=0&sort=score we have 18 anti Borrelia products available on our website. Please have a look and choose as per your requirement. I hope this information is nevertheless helpful. Please do not hesitate to contact us if you need any more advice or information.

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