Overview

  • Product name

    Anti-Kidins220 antibody [P220 1F8/3]
    See all Kidins220 primary antibodies
  • Description

    Mouse monoclonal [P220 1F8/3] to Kidins220
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, ELISA, IHC-P, IPmore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Recombinant Kidins220/ARMS (last 347 amino acids at the carboxy terminus) protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab20211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 220 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.

Target

  • Function

    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • Tissue specificity

    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • Sequence similarities

    Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
  • Domain

    The transmembrane domain mediates interaction with NTRK1.
  • Post-translational
    modifications

    Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ankyrin repeat-rich membrane-spanning protein antibody
    • arms antibody
    • KDIS_HUMAN antibody
    • kidins220 antibody
    • Kinase D interacting substance of 220 kDa antibody
    • Kinase D-interacting substrate of 220 kDa antibody
    • rgd 619949 antibody
    see all

References

This product has been referenced in:

  • Deswal S  et al. Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol 190:1927-35 (2013). Read more (PubMed: 23359496) »
See 1 Publication for this product

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