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    kif2a-antibody-ab3475.pdf

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Signal Transduction Cytoskeleton / ECM Cytoskeleton Motor Proteins Kinesin
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Anti-Kif2a antibody (ab3475)

  • Datasheet
Submit a review Q&A (2)

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Key features and details

  • Rabbit polyclonal to Kif2a
  • Reacts with: Mouse
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Kif2a antibody
    See all Kif2a primary antibodies
  • Description

    Rabbit polyclonal to Kif2a
  • Host species

    Rabbit
  • Specificity

    Detects Kinesin 2 (Kif2a) from mouse tissues.
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Chicken, Cow, Human, Xenopus laevis
  • Immunogen

    Synthetic peptide corresponding to Mouse Kif2a aa 1-11.
    Sequence:

    MVTSLNEDNES


    (Peptide available as ab4992)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Mouse brain homogenate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Motor Proteins
    • Kinesin
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Motor Proteins
    • Kinesin-like

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Function

    Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
  • Sequence similarities

    Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
    Contains 1 kinesin-motor domain.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > spindle. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
  • Target information above from: UniProt accession O00139 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3796 Human
    • Entrez Gene: 16563 Mouse
    • Entrez Gene: 84391 Rat
    • Entrez Gene: 379622 Xenopus laevis
    • Omim: 602591 Human
    • SwissProt: O00139 Human
    • SwissProt: P28740 Mouse
    • SwissProt: Q9WV63 Rat
    • SwissProt: Q91637 Xenopus laevis
    • Unigene: 558351 Human
    • Unigene: 355686 Mouse
    • Unigene: 218992 Rat
    • Unigene: 603 Xenopus laevis
    see all
  • Alternative names

    • CDCBM3 antibody
    • HK2 antibody
    • KIF2 antibody
    • KIF2A antibody
    • KIF2A_HUMAN antibody
    • Kinesin 2 antibody
    • Kinesin heavy chain 2 antibody
    • Kinesin heavy chain member 2 antibody
    • Kinesin heavy chain member 2A antibody
    • Kinesin like protein KIF2A antibody
    • Kinesin-2 antibody
    • Kinesin-like protein KIF2A antibody
    • KNS2 antibody
    • M Kinesin antibody
    see all

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab3475? Please let us know so that we can cite the reference in this datasheet.

    ab3475 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Question

     Dear technical Team, Could you please tell us if article AB3475 Anti SatB2 :  Does this article can be used on formadldehyde fixed(prepared material).  Kind regards,    

    Read More

    Abcam community

    Verified customer

    Asked on Oct 17 2011

    Answer

    Thank you for contacting us and for your interest in our products. I am sorry to confirm that as far as we are aware, ab3475 Kif2a antibody has not been tested in IHC-P.  All tested and guaranteed applications and species are specified on our datasheets, and these are updated as soon as any new information is brought to our attention. I can suggest to consider the following antibody, which has been tested in human and IHC-P ab55383 Mouse monoclonal Anti-Kif2a antibody Tested in:  IHC-P, WB              Reacts with:  Hu  Click here (or use the following: https://www.abcam.com/Kif2a-antibody-ab55383.html).  If you would like to test the ab3475 in IHC-P, please contact me again prior to the purchase by replying to this message as you may be eligible for our testing discount program. Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates. To find out more about our Abreview system, please see the following link: https://www.abcam.com/abreviews I hope this information is helpful. Please do not hesitate to contact me for any further advice or information.    

    Read More

    Abcam Scientific Support

    Answered on Oct 17 2011

    Question

    I thought I would point out to you that there is confusion in your antibody terminology: the kinesin 2 antibody is actually against KIF2, which is NOT kinesin 2 (or II)! It should be called anti-KIF2, since that's what it is!

    Read More

    Abcam community

    Verified customer

    Asked on Jul 20 2004

    Answer

    Thank you for your comment. We will update and change the name of this antibody shortly. The name will be: Kinesin, Heavy Chain, 2 (KIF2).

    Read More

    Abcam Scientific Support

    Answered on Aug 04 2004

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