Overview

  • Product name
    Anti-Kif2a antibody
    See all Kif2a primary antibodies
  • Description
    Rabbit polyclonal to Kif2a
  • Host species
    Rabbit
  • Specificity
    Detects Kinesin 2 (Kif2a) from mouse tissues.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Chicken, Cow, Human, Xenopus laevis
  • Immunogen

    Synthetic peptide corresponding to Mouse Kif2a aa 1-11.
    Sequence:

    MVTSLNEDNES


    (Peptide available as ab4992)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Mouse brain homogenate.

Properties

Applications

Our Abpromise guarantee covers the use of ab3475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Detects a band of approximately 95 kDa (predicted molecular weight: 79 kDa).Can be blocked with KLC1 peptide (ab4992).

This antibody detects a ~95 kDa protein representing KIF 2 from mouse brain homogenate.

Target

  • Function
    Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
  • Sequence similarities
    Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
    Contains 1 kinesin-motor domain.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > spindle. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • CDCBM3 antibody
    • HK2 antibody
    • KIF2 antibody
    • KIF2A antibody
    • KIF2A_HUMAN antibody
    • Kinesin 2 antibody
    • Kinesin heavy chain 2 antibody
    • Kinesin heavy chain member 2 antibody
    • Kinesin heavy chain member 2A antibody
    • Kinesin like protein KIF2A antibody
    • Kinesin-2 antibody
    • Kinesin-like protein KIF2A antibody
    • KNS2 antibody
    • M Kinesin antibody
    see all

References

ab3475 has not yet been referenced specifically in any publications.

Publishing research using ab3475? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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2 reviews or Q&A

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Dear technical Team, Could you please tell us if article AB3475 Anti SatB2 :  Does this article can be used on formadldehyde fixed(prepared material).  Kind regards,

Thank you for contacting us and for your interest in our products. I am sorry to confirm that as far as we are aware, ab3475 Kif2a antibody has not been tested in IHC-P.  All tested and guaranteed applications and species are specified on our datasheet...

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I thought I would point out to you that there is confusion in your antibody terminology: the kinesin 2 antibody is actually against KIF2, which is NOT kinesin 2 (or II)! It should be called anti-KIF2, since that's what it is!

Thank you for your comment. We will update and change the name of this antibody shortly. The name will be: Kinesin, Heavy Chain, 2 (KIF2).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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