Anti-Kif2a antibody (ab3475)

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Overview

  • Product name

    Anti-Kif2a antibody
    See all Kif2a primary antibodies

  • Description

    Rabbit polyclonal to Kif2a

  • Host species

    Rabbit

  • Specificity

    Detects Kinesin 2 (Kif2a) from mouse tissues.

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Chicken, Cow, Human, Xenopus laevis

  • Immunogen

    Synthetic peptide corresponding to Mouse Kif2a aa 1-11.
    Sequence:

    MVTSLNEDNES


    (Peptide available as ab4992)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • Mouse brain homogenate.

Properties

Applications

Our Abpromise guarantee covers the use of ab3475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Detects a band of approximately 95 kDa (predicted molecular weight: 79 kDa).Can be blocked with KLC1 peptide (ab4992).

This antibody detects a ~95 kDa protein representing KIF 2 from mouse brain homogenate.

Target

  • Function

    Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

  • Sequence similarities

    Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
    Contains 1 kinesin-motor domain.

  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > spindle. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • CDCBM3 antibody
    • HK2 antibody
    • KIF2 antibody
    • KIF2A antibody
    • KIF2A_HUMAN antibody
    • Kinesin 2 antibody
    • Kinesin heavy chain 2 antibody
    • Kinesin heavy chain member 2 antibody
    • Kinesin heavy chain member 2A antibody
    • Kinesin like protein KIF2A antibody
    • Kinesin-2 antibody
    • Kinesin-like protein KIF2A antibody
    • KNS2 antibody
    • M Kinesin antibody
    see all

References

ab3475 has not yet been referenced specifically in any publications.

Publishing research using ab3475? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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1-2 of 2 Abreviews or Q&A

Question

 Dear technical Team, Could you please tell us if article AB3475 Anti SatB2 :  Does this article can be used on formadldehyde fixed(prepared material).  Kind regards,    

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Answer

Thank you for contacting us and for your interest in our products. I am sorry to confirm that as far as we are aware, ab3475 Kif2a antibody has not been tested in IHC-P.  All tested and guaranteed applications and species are specified on our datasheets, and these are updated as soon as any new information is brought to our attention. I can suggest to consider the following antibody, which has been tested in human and IHC-P ab55383 Mouse monoclonal Anti-Kif2a antibody Tested in:  IHC-P, WB              Reacts with:  Hu  Click here (or use the following: https://www.abcam.com/index.html?datasheet=55383).  If you would like to test the ab3475 in IHC-P, please contact me again prior to the purchase by replying to this message as you may be eligible for our testing discount program. Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates. To find out more about our Abreview system, please see the following link: https://www.abcam.com/abreviews I hope this information is helpful. Please do not hesitate to contact me for any further advice or information.    

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Question

I thought I would point out to you that there is confusion in your antibody terminology: the kinesin 2 antibody is actually against KIF2, which is NOT kinesin 2 (or II)! It should be called anti-KIF2, since that's what it is!

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Answer

Thank you for your comment. We will update and change the name of this antibody shortly. The name will be: Kinesin, Heavy Chain, 2 (KIF2).

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