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    kif5a--kif5b--kif5c-antibody-ab62105.pdf

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Signal Transduction Cytoskeleton / ECM Cytoskeleton Motor Proteins Kinesin
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Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)

  • Datasheet
Submit a review Submit a question References (1)

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Western blot - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)
  • Immunocytochemistry - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)

Key features and details

  • Rabbit polyclonal to KIF5A + KIF5B + KIF5C
  • Suitable for: ICC, WB
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-KIF5A + KIF5B + KIF5C antibody
    See all KIF5A + KIF5B + KIF5C primary antibodies
  • Description

    Rabbit polyclonal to KIF5A + KIF5B + KIF5C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human KIF5A + KIF5B + KIF5C.
    Database link: Q12840

  • General notes

     This product was previously labelled as Kinesin 5A, Kinesin 5 A + B + C

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Motor Proteins
    • Kinesin

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • K562 whole cell lysate (ab7911)

Applications

Our Abpromise guarantee covers the use of ab62105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use a concentration of 5 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 110 kDa).

Target

  • Relevance

    The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms; this antibody recognizes all three. Mutations in one of the isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.
  • Cellular localization

    Uniformly distributed between soma and neurites in hippocampal neurons
  • Database links

    • Entrez Gene: 3798 Human
    • Entrez Gene: 3799 Human
    • Entrez Gene: 3800 Human
    • SwissProt: O60282 Human
    • SwissProt: P33176 Human
    • SwissProt: Q12840 Human
    • Alternative names

      • KIF5A antibody
      • KIF5B antibody
      • KIF5C antibody
      • Kinesin family member 5A antibody
      • Kinesin family member 5B antibody
      • Kinesin family member 5C antibody
      • KINH antibody
      • KINN antibody
      • NKHC antibody
      • NKHC2 antibody
      see all

    Images

    • Western blot - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)
      Western blot - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)
      Lane 1 : Anti-KIF5A + KIF5B + KIF5C antibody (ab62105) at 0.5 µg/ml
      Lane 2 : Anti-KIF5A + KIF5B + KIF5C antibody (ab62105) at 1 µg/ml

      All lanes : K562 cell lysate

      Predicted band size: 110 kDa
      Observed band size: 120 kDa
      why is the actual band size different from the predicted?

    • Immunocytochemistry - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)
      Immunocytochemistry - Anti-KIF5A + KIF5B + KIF5C antibody (ab62105)

      ab62105 at 5µg/ml staining KIF5A + KIF5B + KIF5C in human K562 cells by Immunohistochemistry.

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab62105? Please let us know so that we can cite the reference in this datasheet.

    ab62105 has been referenced in 1 publication.

    • Zollo M  et al. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. Brain 140:940-952 (2017). WB . PubMed: 28334956

    Customer reviews and Q&As

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