Key features and details
- Rabbit polyclonal to KIF7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-KIF7 antibody
See all KIF7 primary antibodies
DescriptionRabbit polyclonal to KIF7
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rhesus monkey, Gorilla, Orangutan
- HeLa or 293T cell lysate
General notesShelf Life: 1 year from date of receipt
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. The product can be stored for up to 12 months.
Storage bufferpH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab95884 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/2000 - 1/10000. Predicted molecular weight: 151 kDa.|
FunctionActs as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. May also act as a ciliary motor.
Tissue specificityEmbryonic stem cells, melanotic melanoma and Jurkat T-cells.
Sequence similaritiesBelongs to the kinesin-like protein family. KIF27 subfamily.
Contains 1 kinesin-motor domain.
Cellular localizationCell projection > cilium. SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway.
- Information by UniProt
- EQYK340 antibody
- kif7 antibody
- KIF7_HUMAN antibody
ab95884 has been referenced in 2 publications.
- Massa F et al. The deubiquitinating enzyme USP14 controls ciliogenesis and hedgehog signalling. Hum Mol Genet N/A:N/A (2018). PubMed: 30388222
- Ho J et al. Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. PLoS One 9:e108248 (2014). WB ; Human . PubMed: 25265279