Overview

  • Product name

  • Description

    Rabbit polyclonal to Kindlin 2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
    Predicted to work with: Mouse, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Kindlin 2 (internal sequence). The exact sequence is proprietary.
    Database link: Q96AC1

  • Positive control

    • WB: A549 and PC-12 whole cell lysates. IHC-P: Human hepatoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab229539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 78 kDa.

Target

  • Function

    Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
  • Tissue specificity

    Ubiquitous. Found in numerous tumor tissues.
  • Sequence similarities

    Belongs to the kindlin family.
    Contains 1 FERM domain.
    Contains 1 PH domain.
  • Domain

    The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
  • Cellular localization

    Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Within actin stress fibers at cell-ECM focal adhesion sites.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ34213 antibody
    • FLJ44462 antibody
    • UNC112 antibody
    • FERM2_HUMAN antibody
    • Fermitin family homolog 2 antibody
    • Fermt2 antibody
    • KIND2 antibody
    • Kindlin-2 antibody
    • MIG-2 antibody
    • MIG2 antibody
    • Mitogen-inducible gene 2 protein antibody
    • PH domain-containing family C member 1 antibody
    • Pleckstrin homology domain containing family C (with FERM domain) member 1 antibody
    • Pleckstrin homology domain-containing family C member 1 antibody
    • PLEKHC1 antibody
    • UNC112B antibody
    see all

Images

  • Anti-Kindlin 2 antibody (ab229539) at 1/3000 dilution + A549 (human lung carcinoma cell line) whole cell lysate at 30 µg

    Predicted band size: 78 kDa



    7.5% SDS-PAGE gel.

  • Anti-Kindlin 2 antibody (ab229539) at 1/3000 dilution + PC-12 (rat adrenal gland pheochromocytoma cell line) whole cell lysate at 30 µg

    Predicted band size: 78 kDa



    7.5% SDS-PAGE gel.

  • Paraffin-embedded human hepatoma tissue stained for Kindlin 2 using ab229539 at 1/500 dilution in immunohistochemical analysis.

References

ab229539 has not yet been referenced specifically in any publications.

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