Overview

  • Product name

    Anti-Kir4.1/KCNJ10 antibody
    See all Kir4.1/KCNJ10 primary antibodies
  • Description

    Rabbit polyclonal to Kir4.1/KCNJ10
  • Host species

    Rabbit
  • Specificity

    ab192406 detects endogenous levels of Kir4.1/KCNJ10 protein.

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Kir4.1/KCNJ10. The exact sequence is proprietary.
    Database link: P78508

  • Positive control

    • Jurkat whole cell lysate (ab7899); mouse and rat brain tissue lysates.
  • General notes

     This product was previously labelled as Kir4.1

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab192406 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab192406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.

Target

  • Function

    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • Tissue specificity

    Expressed in kidney (at protein level).
  • Involvement in disease

    Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • Sequence similarities

    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • Cellular localization

    Membrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt
  • Database links

  • Alternative names

    • inwardly rectifying subfamily J member 10 antibody
    • ATP dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP sensitive inward rectifier potassium channel 10 antibody
    • ATP-dependent inwardly rectifying potassium channel Kir4.1 antibody
    • ATP-sensitive inward rectifier potassium channel 10 antibody
    • BIRK10 antibody
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1 antibody
    • Inward rectifier K(+) channel Kir1.2 antibody
    • Inward rectifier K+ channel KIR1.2 antibody
    • Inwardly rectifying potassium channel Kir1.2 antibody
    • KCJ10_HUMAN antibody
    • KCNJ 10 antibody
    • Kcnj10 antibody
    • KCNJ13 PEN antibody
    • KIR1.2 antibody
    • KIR4.1 antibody
    • Potassium channel antibody
    • Potassium channel inwardly rectifying subfamily J member 10 antibody
    • Potassium inwardly rectifying channel subfamily J member 10 antibody
    • SESAME antibody
    see all

Images

  • All lanes : Anti-Kir4.1/KCNJ10 antibody (ab192406)

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Mouse brain tissue lysate
    Lane 3 : Rat brain tissue lysate

    Predicted band size: 42 kDa

References

ab192406 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab192406.
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