Key features and details
- Rabbit polyclonal to Kir4.1/KCNJ10
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Kir4.1/KCNJ10 antibody
See all Kir4.1/KCNJ10 primary antibodies
DescriptionRabbit polyclonal to Kir4.1/KCNJ10
ab192406 detects endogenous levels of Kir4.1/KCNJ10 protein.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide within Human Kir4.1/KCNJ10. The exact sequence is proprietary.
Database link: P78508
- Jurkat whole cell lysate (ab7899); mouse and rat brain tissue lysates.
This product was previously labelled as Kir4.1
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.05% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab192406 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Our Abpromise guarantee covers the use of ab192406 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.|
FunctionMay be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
Tissue specificityExpressed in kidney (at protein level).
Involvement in diseaseSeizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
Sequence similaritiesBelongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Cellular localizationMembrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
- Information by UniProt
- inwardly rectifying subfamily J member 10 antibody
- ATP dependent inwardly rectifying potassium channel Kir4.1 antibody
- ATP sensitive inward rectifier potassium channel 10 antibody
ab192406 has not yet been referenced specifically in any publications.