Overview

  • Product name

  • Description

    Goat polyclonal to Kir6.2/BIR
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Kir6.2/BIR aa 18-30 (internal sequence) (Cysteine residue).
    Sequence:

    AEDPAKPRYRARQ


    Database link: NP_000516.3

  • Positive control

    • Human muscle lysate
  • General notes

     This product was previously labelled as Kir6.2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab77637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
ELISA Use at an assay dependent dilution. Antibody detection limit dilution 1:32000.
IHC-P Use a concentration of 3 - 5 µg/ml.

Target

  • Relevance

    ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
  • Cellular localization

    Cell Membrane; Multi-pass membrane protein
  • Database links

  • Alternative names

    • ATP sensitive inward rectifier potassium channel 11 antibody
    • Beta cell inward rectifier subunit antibody
    • BIR antibody
    • HHF 2 antibody
    • HHF2 antibody
    • IKATP antibody
    • Inward rectifier K(+) channel Kir6.2 antibody
    • Inwardly rectifying potassium channel KIR6.2 antibody
    • IRK 11 antibody
    • IRK11 antibody
    • KCNJ11 antibody
    • Kir 6.2 antibody
    • Kir6.2 antibody
    • MGC133230 antibody
    • PHHI antibody
    • Potassium channel inwardly rectifing subfamily J member 11 antibody
    • Potassium channel, inwardly rectifying subfamily J member 11 antibody
    • Potassium inwardly rectifying channel J11 antibody
    • TNDM 3 antibody
    • TNDM3 antibody
    see all

Images

  • Anti-Kir6.2/BIR antibody (ab77637) at 0.1 µg/ml + Human Muscle lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 44 kDa
    Observed band size: 44 kDa

  • ab77637 at 3µg/ml staining Kir6.2/BIR in human pancreas tissue section by Immunohistochemistry (Formalin/ PFA-fixed paraffin-embedded tissue sections). The tissue sections underwent antigen retrieval by steam with citrate buffer pH 6.0. The AP staining procedure was used for staining.

References

ab77637 has not yet been referenced specifically in any publications.

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