Overview

  • Product name
    Anti-Kir7.1 antibody - N-terminal
  • Description
    Rabbit polyclonal to Kir7.1 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Guinea pig
  • Immunogen

    Synthetic peptide within Human Kir7.1 aa 74-103 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: O60928

  • Positive control
    • Human stomach tissue; MDA-MB435 cell line lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab170631 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

Target

  • Function
    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
  • Tissue specificity
    Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.
  • Involvement in disease
    Snowflake vitreoretinal degeneration
    Leber congenital amaurosis 16
  • Sequence similarities
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily.
  • Post-translational
    modifications
    Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • inwardly rectifying subfamily J member 13 antibody
    • Inward rectifier K(+) channel Kir7.1 antibody
    • Inward rectifier potassium channel 13 antibody
    • KCJ13_HUMAN antibody
    • KCNJ13 antibody
    • KIR1.4 antibody
    • KIR7.1 antibody
    • LCA16 antibody
    • Potassium channel antibody
    • Potassium inwardly rectifying channel subfamily J member 13 antibody
    • SVD antibody
    see all

Images

  • Anti-Kir7.1 antibody - N-terminal (ab170631) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

    Predicted band size: 41 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human stomach tissue labeling Kir7.1 with ab170631 at 1/10 dilution, followed by peroxidase-conjugated secondary antibody and DAB staining.

References

ab170631 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab170631.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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