Overview

  • Product name

  • Description

    Rabbit polyclonal to KLC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human KLC1.
    Database link: Q07866

  • Positive control

    • SW480, 22RV1, BT474, MCF7 and mouse brain extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab187179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB 1/500 - 1/2000. Predicted molecular weight: 65 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
  • Tissue specificity

    Found in a variety of tissues. Mostly abundant in brain and spine.
  • Sequence similarities

    Belongs to the kinesin light chain family.
    Contains 6 TPR repeats.
  • Post-translational
    modifications

    Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
  • Cellular localization

    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links

  • Alternative names

    • Kinesin 2 60/70kDa antibody
    • Kinesin light chain 1 antibody
    • Kinesin2 antibody
    • KLC 1 antibody
    • KLC antibody
    • Klc1 antibody
    • KLC1_HUMAN antibody
    • KNS 2 antibody
    • KNS 2A antibody
    • KNS2 antibody
    • KNS2A antibody
    • Medulloblastoma antigen MU MB 2.50 antibody
    • MGC15245 antibody
    see all

Images

  • Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab187179. Blue DAPI for nuclear staining.
  • All lanes : Anti-KLC1 antibody (ab187179) at 1/500 dilution

    Lane 1 : SW480 cell extract
    Lane 2 : 22RV1 cell extract
    Lane 3 : BT474 cell extract
    Lane 4 : MCF7 cell extract
    Lane 5 : Mouse brain cell extract

    Predicted band size: 65 kDa

References

This product has been referenced in:

  • Dinamarca MC  et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun 10:1331 (2019). Read more (PubMed: 30902970) »
  • Jang WH  et al. Interaction of FUN14 domain containing 1, a mitochondrial outer membrane protein, with kinesin light chain 1 via the tetratricopeptide repeat domain. Biomed Rep 6:46-50 (2017). Read more (PubMed: 28123706) »
See all 2 Publications for this product

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