Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab170364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 53 kDa.
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

Target

  • Function
    Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
  • Sequence similarities
    Belongs to the Sp1 C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Early growth response, alpha antibody
    • Early growth response, alpha like antibody
    • EGR A antibody
    • EGR alpha antibody
    • EGR(A) antibody
    • EGR-alpha antibody
    • EGRA antibody
    • Egral antibody
    • EGRalpha antibody
    • Gdnfif antibody
    • KLF 10 antibody
    • KLF10 antibody
    • KLF10_HUMAN antibody
    • Krueppel like factor 10 antibody
    • Krueppel like factor10 antibody
    • Krueppel-like factor 10 antibody
    • Kruppel like factor 10 antibody
    • mGIF antibody
    • TGF-beta- inducible early gene antibody
    • TGFB inducible early growth response 1 antibody
    • TGFB inducible early growth response antibody
    • TGFB inducible early growth response protein 1 antibody
    • TGFB-inducible early growth response protein 1 antibody
    • TIEG 1 antibody
    • TIEG antibody
    • TIEG-1 antibody
    • TIEG1 antibody
    • Transforming growth factor beta inducible early growth response antibody
    • Transforming growth factor beta inducible early growth response protein 1 antibody
    • Transforming growth factor-beta-inducible early growth response protein 1 antibody
    • Zinc finger transcription factor TIEG antibody
    see all

Images

  • All lanes : Anti-KLF10 antibody (ab170364) at 1/50 dilution

    Lane 1 : Lysate from nontransfected 293 cells
    Lane 2 : Lysate from 293 cells transiently transfected with KLF10

    Lysates/proteins at 2 µg per lane.

    Predicted band size: 53 kDa

  • Flow cytometry analysis of 293 cells labeling KLF10 (green, right histogram), using ab170364 at a 1/10 dilution, and negative control cells (blue, left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies was used for the analysis.

References

ab170364 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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