• Product name

    Anti-KLF6 antibody
  • Description

    Rabbit polyclonal to KLF6
  • Host species

  • Tested applications

    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human KLF6 aa 150-205.


    Database link: Q99612

  • Positive control

    • IHC-P: Human gallbladder tissue. ICC/IF: SK-MEL-30 cells.



Our Abpromise guarantee covers the use of ab241385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
  • Tissue specificity

    Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
  • Involvement in disease

    Defects in KLF6 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
    Defects in KLF6 are a cause of prostate cancer (PC) [MIM:176807]. Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • Sequence similarities

    Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • Domain

    The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • B cell derived protein 1 antibody
    • B cell-derived 1 antibody
    • B-cell-derived protein 1 antibody
    • BCD1 antibody
    • CBA1 antibody
    • COPEB antibody
    • Core promoter element-binding protein antibody
    • CPBP antibody
    • GBF antibody
    • GC rich binding factor antibody
    • GC rich sites binding factor GBF antibody
    • GC-rich sites-binding factor GBF antibody
    • Klf6 antibody
    • KLF6_HUMAN antibody
    • Krueppel-like factor 6 antibody
    • Krueppel-like factor 6 isoform C antibody
    • Kruppel like zinc finger protein Zf9 antibody
    • PAC1 antibody
    • Proto-oncogene BCD1 antibody
    • Protooncogene B cell derived 1 antibody
    • ST12 antibody
    • Suppression of tumorigenicity 12 (prostate) antibody
    • Suppressor of tumorigenicity 12 protein antibody
    • Transcription factor Zf9 antibody
    • Zf9 antibody
    see all


  • SK-MEL-30 cells stained for KLF6 using ab241385 at 4 µg/ml (green) in ICC/IF.

  • Formalin-fixed, paraffin-embedded human gallbladder tissue stained for KLF6 with ab241385 at 1/1000 dilution in immunohistochemical analysis.


ab241385 has not yet been referenced specifically in any publications.

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