Overview

  • Product name
    Anti-KLRG1 antibody [2F1]
    See all KLRG1 primary antibodies
  • Description
    Syrian hamster monoclonal [2F1] to KLRG1
  • Host species
    Syrian hamster
  • Specificity
    ab25054 recognises KLRG1.
  • Tested applications
    Suitable for: Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Activated NK (A-LAK) cells from B6 (H-2b) mice

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C. Do Not Freeze.
  • Storage buffer
    pH: 7.2
    Preservative: 0.09% Sodium azide
    Constituents: 0.88% Sodium chloride, 0.12% Monobasic dihydrogen sodium phosphate
  • Concentration information loading...
  • Purity
    Affinity purified
  • Purification notes
    Purified from TCS
  • Clonality
    Monoclonal
  • Clone number
    2F1
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab25054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab18474 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.

Target

  • Function
    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • Tissue specificity
    Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2F1 Ag antibody
    • 2F1 antibody
    • C type lectin domain family 15 member A antibody
    • C-type lectin domain family 15 member A antibody
    • CLEC15A antibody
    • ITIM containing receptor MAFA L antibody
    • ITIM-containing receptor MAFA-L antibody
    • Killer cell lectin like receptor G1 antibody
    • Killer cell lectin like receptor subfamily G member 1 antibody
    • Killer cell lectin-like receptor subfamily G member 1 antibody
    • KLRG 1 antibody
    • KLRG1 antibody
    • KLRG1 protein antibody
    • KLRG1_HUMAN antibody
    • MAFA 2F1 antibody
    • MAFA antibody
    • MAFA L antibody
    • MAFA like antibody
    • MAFA like receptor antibody
    • MAFA-like receptor antibody
    • MAFAL antibody
    • Mast cell function associated antigen (ITIM containing) antibody
    • Mast cell function associated antigen antibody
    • Mast cell function-associated antigen 2F1 antibody
    • Mast cell function-associated antigen antibody
    • Mast cell function-associated antigen, rat, homolog of antibody
    • MGC13600 antibody
    see all

References

This product has been referenced in:
  • Corral L  et al. NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur J Immunol 30:920-30 (2000). Read more (PubMed: 10741410) »
  • Hanke T  et al. 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol 28:4409-17 (1998). Read more (PubMed: 9862378) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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