Overview

  • Product name
    Anti-KLRG1 antibody [EPR11237]
    See all KLRG1 primary antibodies
  • Description
    Rabbit monoclonal [EPR11237] to KLRG1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human KLRG1 aa 1-100. The exact sequence is proprietary.
    Database link: Q96E93

  • Positive control
    • Human thymus, HUT-78, THP1, Jurkat and Raji lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Constituents: 0.35% Sodium citrate, 0.17% Sodium chloride, 0.03% EDTA, 59% PBS, 40% Glycerol, 0.05% BSA
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    EPR11237
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 22 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function
      Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
    • Tissue specificity
      Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
    • Sequence similarities
      Contains 1 C-type lectin domain.
    • Domain
      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2F1 Ag antibody
      • 2F1 antibody
      • C type lectin domain family 15 member A antibody
      • C-type lectin domain family 15 member A antibody
      • CLEC15A antibody
      • ITIM containing receptor MAFA L antibody
      • ITIM-containing receptor MAFA-L antibody
      • Killer cell lectin like receptor G1 antibody
      • Killer cell lectin like receptor subfamily G member 1 antibody
      • Killer cell lectin-like receptor subfamily G member 1 antibody
      • KLRG 1 antibody
      • KLRG1 antibody
      • KLRG1 protein antibody
      • KLRG1_HUMAN antibody
      • MAFA 2F1 antibody
      • MAFA antibody
      • MAFA L antibody
      • MAFA like antibody
      • MAFA like receptor antibody
      • MAFA-like receptor antibody
      • MAFAL antibody
      • Mast cell function associated antigen (ITIM containing) antibody
      • Mast cell function associated antigen antibody
      • Mast cell function-associated antigen 2F1 antibody
      • Mast cell function-associated antigen antibody
      • Mast cell function-associated antigen, rat, homolog of antibody
      • MGC13600 antibody
      see all

    Images

    • All lanes : Anti-KLRG1 antibody [EPR11237] (ab170959) at 1/1000 dilution

      Lane 1 : Human thymus lysate
      Lane 2 : HUT-78 lysate
      Lane 3 : THP1 lysate
      Lane 4 : Jurkat lysate
      Lane 5 : Raji lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Developed using the ECL technique.

      Predicted band size: 22 kDa

    References

    This product has been referenced in:
    • Müller-Durovic B  et al. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. J Immunol 197:2891-9 (2016). Read more (PubMed: 27566818) »

    See 1 Publication for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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