Overview

  • Product name

    Anti-KMT3A / HYPB / HIF-1 antibody
    See all KMT3A / HYPB / HIF-1 primary antibodies
  • Description

    Rabbit polyclonal to KMT3A / HYPB / HIF-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant full length protein corresponding to Human KMT3A/ HYPB/ HIF-1.
    Database link: Q9BYW2

  • Positive control

    • IHC-P: Human tonsil and testis tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
  • Tissue specificity

    Ubiquitously expressed.
  • Sequence similarities

    Belongs to the histone-lysine methyltransferase family. SET2 subfamily.
    Contains 1 AWS domain.
    Contains 1 post-SET domain.
    Contains 1 SET domain.
    Contains 1 WW domain.
  • Domain

    The low charge region mediates the transcriptional activation activity.
  • Post-translational
    modifications

    May be automethylated.
  • Cellular localization

    Nucleus. Chromosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 2.1.1.43 antibody
    • FLJ16420 antibody
    • FLJ22472 antibody
    • FLJ23184 antibody
    • FLJ45883 antibody
    • HBP231 antibody
    • HIF 1 antibody
    • HIF-1 antibody
    • HIF1 antibody
    • HIP-1 antibody
    • Histone lysine N methyltransferase SETD2 antibody
    • Histone-lysine N-methyltransferase SETD2 antibody
    • hSET2 antibody
    • HSPC069 antibody
    • Huntingtin interacting protein 1 antibody
    • Huntingtin interacting protein antibody
    • Huntingtin interacting protein B antibody
    • Huntingtin interacting protein HYPB antibody
    • Huntingtin yeast partner B antibody
    • Huntingtin-binding protein, 231-KD antibody
    • Huntingtin-interacting protein 1 antibody
    • Huntingtin-interacting protein B antibody
    • HYPB antibody
    • KIAA1732 antibody
    • KMT3A antibody
    • Lysine N methyltransferase 3A antibody
    • Lysine N-methyltransferase 3A antibody
    • p231HBP antibody
    • SET domain containing 2 antibody
    • SET domain-containing protein 2 antibody
    • SET2 antibody
    • SETD2 antibody
    • SETD2_HUMAN antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human tonsil tissue stained for KMT3A / HYPB / HIF-1 using ab230434 at 5 µg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human testis tissue stained for KMT3A / HYPB / HIF-1 with ab230434 at 5 µg/ml in immunohistochemical analysis.

References

ab230434 has not yet been referenced specifically in any publications.

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