Overview

  • Product name

    KN-93, CaM kinase II inhibitor
  • Description

    Potent, cell-permeable CaM kinase II inhibitor. Potent voltage gated K+ channel blocker.
  • Biological description

    Potent, cell-permeable CaM kinase II inhibitor (IC50 = 370 nM). Potent voltage gated K+ channel blocker (IC50 = 307 nM, KV1.5). Analog of water soluble KN-93 (ab120980). Suppresses early afterdepolarization. Induces ROS generation and apoptosis. Shows central effects in vivo.
  • Purity

    > 98%
  • CAS Number

    139298-40-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Farahmandfar M  et al. Possible interaction of hippocampal nitric oxide and calcium/calmodulin-dependent protein kinase II on reversal of spatial memory impairment induced by morphine. Eur J Pharmacol 751:99-111 (2015). Read more (PubMed: 25661847) »
  • Rokhlin OW  et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther 9:224-35 (2010). Read more (PubMed: 20023417) »
  • Anderson ME  et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther 287:996-1006 (1998). Read more (PubMed: 9864285) »

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