KNK 437 (Heat Shock Protein Inhibitor I), heat shock protein biosynthesis inhibitor (ab146410)

Overview

  • Product name

    KNK 437 (Heat Shock Protein Inhibitor I), heat shock protein biosynthesis inhibitor
  • Description

    Selective heat shock protein biosynthesis inhibitor
  • Alternative names

    • KNK437
  • Biological description

    Selective heat shock protein biosynthesis inhibitor. Induces neurite outgrowth in PC12 cells. Thermosensitizes cancer cells. Inhibits thermotolerance in vivo.

  • Purity

    > 98%
  • CAS Number

    218924-25-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
  • Molecular weight

    245.23
  • Molecular formula

    C13H11NO4
  • PubChem identifier

    24906297
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(C(=O)C1=CC2=CC3=C(C=C2)OCO3)C=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Koike T  et al. The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells. Neurosci Lett 410:212-7 (2006). Read more (PubMed: 17055158) »
  • Koishi M  et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res 7:215-9 (2001). Read more (PubMed: 11205912) »
  • Yokota S  et al. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res 60:2942-8 (2000). Read more (PubMed: 10850441) »

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