Human Cytokine Antibody Array D (40 Targets) - Quantitative

타겟 정보

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed : 27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed : 10924499, PubMed : 10969042, PubMed : 11815627, PubMed : 14504186, PubMed : 19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed : 10969042, PubMed : 11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed : 11815627, PubMed : 27217402, PubMed : 28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed : 18424768, PubMed : 19185582).. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63.. Isoform 2. Non-functional as a carboxypeptidase.. Isoform 2. (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.

Additional targets

PGA3,FGF1,ALB,JAML,ANGPT4,TNFSF13B,CD163,CLU,CRTAM,CXCL14,CST3,DCN,DLL1,AHSG,FOLR1,FURIN,,CSF3R,SPINT2,IL17RB,IL27,LAG3,Low-density lipoprotein receptor,TNFRSF11A,RBP4,SOST,SDC1,TNFRSF13B,TFPI,THBS1,TNFRSF10B,TNFSF11,TNNI2,Urokinase-type plasminogen activator,CDH5,CCN4

대체 명칭 보기

UNQ868/PRO1885, ACE2, Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, Metalloprotease MPROT15, ACEH, ACE-related carboxypeptidase, CD114, GCSFR, CSF3R, Granulocyte colony-stimulating factor receptor, G-CSF receptor, G-CSF-R, PRO2222, RBP4, Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, FOLR, FOLR1, Folate receptor alpha, FR-alpha, Adult folate-binding protein, Folate receptor 1, KB cells FBP, Ovarian tumor-associated antigen MOv18, FBP, MIP2G, NJAC, SCYB14, PSEC0212, UNQ240/PRO273, CXCL14, C-X-C motif chemokine 14, Chemokine BRAK, MIP-2G, Small-inducible cytokine B14, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, ALB, Albumin, CD223, FDC, LAG3, Lymphocyte activation gene 3 protein, LAG-3, TNNI2, CD262, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186, TNFRSF10B, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin, CST3, UNQ146/PRO172, DLL1, Delta-like protein 1, Drosophila Delta homolog 1, Delta1, H-Delta-1, CD163, M130, Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, IL27A, IL30, IL27, Interleukin-27 subunit alpha, IL-27 subunit alpha, IL-27-A, IL27-A, Interleukin-30, p28, Urokinase-type plasminogen activator, U-plasminogen activator, uPA, PLAU, Low-density lipoprotein receptor, LDL receptor, LDLR, CD265, RANK, TNFRSF11A, Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, Receptor activator of NF-KB, ODFR, CD254, OPGL, RANKL, TRANCE, TNFSF11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF, CD138, SDC, SDC1, Syndecan-1, SYND1, FUR, PACE, PCSK3, FURIN, Furin, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, APOJ, CLI, KUB1, AAG4, CLU, Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Ku70-binding protein 1, NA1/NA2, Sulfated glycoprotein 2, Testosterone-repressed prostate message 2, Apo-J, SGP-2, TRPM-2, LACI, TFPI1, TFPI, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, Lipoprotein-associated coagulation inhibitor, EPI, FETUA, PRO2743, AHSG, Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, CD144, Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CDH5, CD257, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738, TNFSF13B, Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, B-cell-activating factor, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, TALL-1, FGFA, FGF1, Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, Endothelial cell growth factor, Heparin-binding growth factor 1, aFGF, ECGF, HBGF-1, UNQ2976/PRO7455/PRO7476, SOST, Sclerostin, ANG3, ANG4, ANGPT4, Angiopoietin-4, ANG-4, Angiopoietin-3, ANG-3, SLRR1B, DCN, Decorin, Bone proteoglycan II, PG-S2, PG40, CD267, TACI, TNFRSF13B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor, CD355, Cytotoxic and regulatory T-cell molecule, Class-I MHC-restricted T-cell-associated molecule, CRTAM, HAI2, KOP, SPINT2, Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, Placental bikunin, HAI-2, TSP, TSP1, THBS1, Thrombospondin-1, Glycoprotein G, CRL4, EVI27, IL17BR, UNQ2501/PRO19612, IL17RB, Interleukin-17 receptor B, IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, Interleukin-17B receptor, IL-17Rh1, IL17Rh1, IL-17B receptor, AMICA1, UNQ722/PRO1387, JAML, Junctional adhesion molecule-like, Adhesion molecule interacting with CXADR antigen 1, Dendritic cell-specific protein CREA7-1, WISP1, CCN4, CCN family member 4, WNT1-inducible-signaling pathway protein 1, Wnt-1-induced secreted protein, WISP-1, Pepsin A-3, Pepsinogen-3, PGA3, G-protein coupled receptor-associated sorting protein 2, GASP-2, GPRASP2