Monoacylglycerol Lipase/MGL Inhibitor Screening Kit (Fluorometric)
Be the first to review this product! 리뷰 제출
|
(1 출판물)
Monoacylglycerol Lipase/MGL Inhibitor Screening Kit provides a straightforward method to identify inhibitors of human MGL.
대체 명칭 보기
Monoglyceride lipase, MGL, HU-K5, Lysophospholipase homolog, Lysophospholipase-like, Monoacylglycerol lipase, MAGL, MGLL
- FuncS
Supplier Data
Functional Studies - Monoacylglycerol Lipase/MGL Inhibitor Screening Kit (Fluorometric) (AB283388)
IC50 determination for MAGL Control Inhibitor. IC50 was 75 pM.
- FuncS
Supplier Data
Functional Studies - Monoacylglycerol Lipase/MGL Inhibitor Screening Kit (Fluorometric) (AB283388)
Reaction kinetics of MAGL Enzyme in the presence and absence of Control Inhibitor (10 pM).
- Other
Supplier Data
Other - Monoacylglycerol Lipase/MGL Inhibitor Screening Kit (Fluorometric) (AB283388)
Representative image of Monoacylglycerol Lipase/MGL Inhibitor Screening Kit (Fluorometric) ab283388
Components shown from left to right :
- Human Monoacylglycerol Lipase
- MAGL Inhibitor
- MAGL Substrate
- MAGL Assay Buffer
Note : The vial labels shown in this image use generic names for illustrative purposes only and may not exactly match the specific component names included in the kit.
Note : Colors of solutions in image may not precisely match the shade of colors in the actual kit.
보완 제품
Reactivity 정보
제품 세부 정보
Monoacylglycerol Lipase/MGL Inhibitor Screening Kit provides a straightforward method to identify inhibitors of human MGL. In the assay, human recombinant MGL is used to cleave an MGL substrate, resulting in a fluorescence increase that is abrogated by the presence of an inhibitor for this enzyme. Specific inhibitors for this enzyme are of great clinical interest due to the central role for MGL in lipid metabolism and energy storage.
Simple one-step reaction. Takes only 1-2 hours.
This product is manufactured by BioVision, an Abcam company and was previously called K474 Monoacylglycerol Lipase Inhibitor Screening Kit (Fluorometric). K474-100 is the same size as the 100 test size of ab283388.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
제품 구성
특성 및 보관 정보
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MGL contributes to the regulation of energy homeostasis by controlling the levels of 2-monoacylglycerol. It catalyzes the final step in the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) which is important for modulating inflammation pain and mood. MGL is not known to be part of a larger protein complex. In the brain its action helps terminate endocannabinoid signaling therefore influencing neurotransmission and synaptic plasticity.
Pathways
MGL plays a critical role in the endocannabinoid and glycerolipid metabolism pathways. In the endocannabinoid system it interacts with the cannabinoid receptors CB1 and CB2 by regulating 2-AG levels. The protein's role in glycerolipid metabolism involves its interaction with long-chain acyl-CoA synthetase and fatty acid oxidation pathways which are essential for maintaining lipid balance and cellular energy.
타겟 정보
제품이 사용된 논문 (1)
Recent publications for all applications. Explore the 전체 목록 and refine your search
International journal of molecular sciences 26: PubMed40332072
2025
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com