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AB236473

Reticulum Stain Kit (Modified Gomori's)

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(4 제품이 사용된 논문 )

The Reticulum Stain Kit (Modified Gomori's) is intended for use in histological demonstration of reticular fibers.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Reticulum Stain Kit (Modified Gomori's) (AB236473)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Reticulum Stain Kit (Modified Gomori's) (AB236473)

ab236473 Reticulum Stain Kit (Modified Gomori's) staining formalin-fixed-paraffin embedded human liver.

주요 정보

샘플 타입

Tissue sections

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보완 제품

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제품 세부 정보

The Reticulum Stain Kit (Modified Gomori's) is intended for use in histological demonstration of reticular fibers. The main function of reticular fibers is to provide support. They are normally found throughout the body, particularly in liver, lymph node, spleen and kidney. Ammoniacal silver stains are the most commonly used methods for demonstration of reticular fibers.

Staining Interpretation

Reticulum Grey/Black
Nuclei Pink/Red

Control Tissue: Liver, Kidney, Lymph Node, Spleen

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제품 구성

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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
Multi
보관 정보
Please refer to protocols
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Reticular fibers also known as reticulin fibers serve as a supportive scaffolding in connective tissues. They primarily consist of type III collagen a protein with a molecular mass that varies but is generally around 300 kDa. These fibers form intricate networks that are abundantly expressed in the extracellular matrix of several organs including the liver lymph nodes and bone marrow. Their unique structure permits a certain degree of flexibility and elasticity offering support to the surrounding cellular components.
Biological function summary

The structural framework provided by reticular fibers supports cellular organization in connective tissue environments. These fibers often associate with other extracellular matrix components such as glycoproteins and proteoglycans to form a complex that enhances the maintenance and resilience of connective tissue. They play an important role in filtering bodily fluids due to presence in lymphoid tissues like the spleen and lymph nodes where they aid in trapping particulates and pathogens.

Pathways

Type III collagen in reticular fibers functions within the complex processes of tissue organization and repair. Specifically they are part of the extracellular matrix pathway which includes interactions with other collagens and matrix metalloproteinases. Another related pathway is the wound healing pathway where type III collagen collaborates with fibronectin and type I collagen to facilitate tissue repair and regeneration.

Alterations in reticular fiber networks associate with certain conditions such as liver fibrosis and Ehlers-Danlos syndrome. In liver fibrosis excessive reticular fiber deposition occurs leading to tissue stiffness due to increased type III collagen production. In Ehlers-Danlos syndrome mutations in the genes coding for collagen can disrupt reticular fiber function affecting tissue elasticity and strength. In both conditions changes in other collagens like type I collagen are often observed which further complicate the tissue integrity and contribute to disease pathology.
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제품 프로토콜

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타겟 정보

See full target information Formaldehyde
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Basic research in cardiology 119:957-971 PubMed39404904

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Journal of cutaneous pathology 48:24-33 PubMed33410541

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Oral focal mucinosis: A multi-institutional study and literature review.

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