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AB120511

1-Phenylbiguanide, 5-HT3 receptor agonist

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MW 177.21 Da, Purity >99%. 5-HT3 receptor agonist (EC50 = 0.64 nM). Increases dopamine release. Achieve your results faster with highly validated, pure and trusted compounds.

대체 명칭 보기

5 HT3 D, 5 HT3 E, 5 HTR3B, 5 Hydroxytryptamine Serotonin Receptor 3a, 5 hydroxytryptamine (serotonin) receptor 3 family member D, 5 hydroxytryptamine (serotonin) receptor 3, family member C, 5 hydroxytryptamine (serotonin) receptor 3C ionotropic, 5 hydroxytryptamine 3 receptor, 5 hydroxytryptamine 3 receptor B subunit, 5 hydroxytryptamine receptor 3 subunit C, 5 hydroxytryptamine receptor 3C, 5 hydroxytryptamine receptor 3D, 5 hydroxytryptamine serotonin receptor 3B, 5-HT-3, 5-HT3 receptor subunit E splice variant HTR3Ea, 5-HT3E, 5-HT3R, 5-HT3c1, 5-hydroxytryptamine (serotonin) receptor 3 family member E, 5-hydroxytryptamine receptor 3, 5-hydroxytryptamine receptor 3 subunit D, 5-hydroxytryptamine receptor 3 subunit E, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3B, 5-hydroxytryptamine receptor 3E, 5HT3B_HUMAN, 5HT3E, CPC12, CPC8, CPC9, CPCJ, CYP2C, CYP2C10, HTR3, HTR3D, HTR3E, Htr3a, Htr3b, MGC119636, MGC119637, MGC120035, MGC120036, MGC120037, P450 PB 1, P450C2C, P450IIC19, P450IIC9, SEROTONIN 5-HT-3E RECEPTOR, Serotonin 5-HT-3D receptor, Serotonin gated ion channel subunit, Serotonin receptor 3B, Serotonin receptor 3C, Serotonin receptor 3D, Serotonin receptor 3E, Serotonin-gated ion channel receptor, serotonin receptor 3 subunit E

1 이미지
Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)
  • Chemical Structure

Lab

Chemical Structure - 1-Phenylbiguanide, 5-HT3 receptor agonist (AB120511)

2D chemical structure image of ab120511, 1-Phenylbiguanide, 5-HT3 receptor agonist

주요 정보

CAS 번호

102-02-3

Purity

>99%

제형

Solid

form

Molecular weight

177.21 Da

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>1</sub>N<sub>5</sub>

PubChem

4780

Nature

Synthetic

Solubility

Soluble in water to 100 mM

생화학적 명칭

1-Phenylbiguanide

생물학적 정보

5-HT3 receptor agonist (EC50 = 0.64 nM). Increases dopamine release.

Canonical SMILES

C1=CC=C(C=C1)N=C(N)N=C(N)N

InChi

InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)

InChiKey

CUQCMXFWIMOWRP-UHFFFAOYSA-N

IUPAC Name

1-(diaminomethylidene)-2-phenylguanidine

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보완 제품

Primary Antibodies

AB109237

Anti-YY1 antibody [EPR4652] - Nuclear Loading Control

RabMAb|Recombinant|Lab Essentials|Advanced Validation|20ul selling size

Flow Cytometry (Intracellular) - Anti-YY1 antibody [EPR4652] - Nuclear Loading Control (AB109237)

  • 4
  • 10
Primary Antibodies

AB90055

Anti-ID2 antibody [OTI10C3]

Immunocytochemistry/ Immunofluorescence - Anti-ID2 antibody [OTI10C3] (AB90055)

  • 0
  • 0
Primary Antibodies

AB131272

Anti-ACTL6A antibody [EPR7443]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTL6A antibody [EPR7443] (AB131272)

  • 0
  • 0
Primary Antibodies

AB259839

Anti-BRD9 antibody [EPR23888-5]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD9 antibody [EPR23888-5] (AB259839)

  • 4
  • 1
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
Ambient
적절한 장기 보관 조건
Ambient
보관 정보
The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The 5-HT3 receptor a serotonin receptor subtype mechanically functions as a ligand-gated ion channel. Alternate names for this receptor include 5HT3A 5HT3B HTR3C and 5HT3E. The receptor mainly consists of a pentameric structure made up of these five subunits which together allow the flow of cations across the cell membrane. The exact mass of the individual receptor subunits can vary but they roughly range between 50 and 60 kDa. The 5-HT3 receptors primarily express in the gastrointestinal tract and the central nervous system where they mediate fast excitatory synaptic transmission.
Biological function summary

The 5-HT3 receptor plays a critical role in neurotransmission and is part of a complex involved in mediating various physiological processes. It functions by binding to serotonin causing the receptor to open and allowing cation influx which depolarizes the neuron's membrane. Moreover the receptor is involved in processes like vomiting and anxiety regulation. As a member of a larger family of neurotransmitter receptors it influences how neurons communicate and ultimately impacts functions like mood and gut motility.

Pathways

5-HT3 receptors integrate into the serotonin signaling pathway which is essential in regulating mood cognition and perception. They also play a role in the emetic response pathway involving other proteins like the cytochrome P450 enzymes such as cytochrome P450 2C8 2C9 2C12 and 2C19 which are involved in drug metabolism and detoxification processes. The interaction between these pathways highlights the receptor's importance in maintaining neurotransmitter balance and drug interactions inside the body.

The 5-HT3 receptor has implications for conditions like irritable bowel syndrome (IBS) and chemotherapy-induced nausea and vomiting (CINV). Dysregulation of this receptor can lead to altered neurotransmission affecting both gastrointestinal and neurological health. In IBS abnormal receptor activity can cause disrupted gut motility while connection with cytochrome P450 enzymes influences susceptibility to CINV. The receptor's modulation provides therapeutic targets where 5-HT3 receptor antagonists and agonists like phenylbiguanide and other compounds serve as treatment options to alleviate symptoms associated with these disorders.
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제품 프로토콜

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in bioengineering and biotechnology 9:703241 PubMed34513812

2021

Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenglong Zhong,Yuqing Tian,Xiaoming Luo,Jianjie Zou,Lin Wu,Julong Tian
제품이 사용된 논문 모두 보기
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Product promise

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