4-Aminopyridine (4-AP), K+ channel blocker
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(14 제품이 사용된 논문 )
MW 94.11 Da, Purity >99%. Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity *in vitro*.
대체 명칭 보기
ATFB7, Cyclic GMP gated potassium channel, HK 2, HPCN1, Hck 1, Inward rectifier K(+) channel Kir7.1, Inward rectifier potassium channel 13, KCA10_HUMAN, KCJ13_HUMAN, KCNA 10, KCNA5_HUMAN, KCNB2_HUMAN, KCND1_HUMAN, KCNJ13, KIR1.4, KIR7.1, KV1.5, Kcn 1, Kv1.8, Kv4.1, LCA16, OTTHUMP00000025805, OTTHUMP00000025806, PCN1, Potassium channel, Potassium channel, insulinoma and islet cell, Potassium channel, voltage-gated, shaker-related subfamily, member 5, Potassium inwardly rectifying channel subfamily J member 13, Potassium voltage gated channel Shal related subfamily member 1, Potassium voltage gated channel shaker related subfamily member 10, Potassium voltage-gated channel subfamily A member 10, Potassium voltage-gated channel subfamily A member 5, Potassium voltage-gated channel subfamily B member 2, Potassium voltage-gated channel subfamily D member 1, SVD, Shal type potassium channel, Voltage gated potassium channel Kv4.1, Voltage-gated potassium channel HK2, Voltage-gated potassium channel subunit Kv1.5, Voltage-gated potassium channel subunit Kv1.8, Voltage-gated potassium channel subunit Kv2.2, Voltage-gated potassium channel subunit Kv4.1, cardiac potassium channel, delayed rectifier potassium channel protein, insulinoma and islet potassium channel, inwardly rectifying subfamily J member 13, mShal, potassium channel 1, potassium channel Kv2.2, voltage-gated potassium channel protein Kv1.5
- ICC/IF
PubMed
Immunocytochemistry/ Immunofluorescence - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)
4-AP-induced LFPs provoke AP firing from SST-interneurons. Representative images of GCaMP3 signal in a visual field containing several SST interneurons before (left) and during (right) LFPP-CA3/DG (induced with 4-AP).
Grosser S et al., PloS one., 9(1) : e86250. Fig 3A.; doi : 10.1371/journal.pone.0086250
Image from Grosser S et al., PloS one., 9(1): e86250. Fig 3A.; doi: 10.1371/journal.pone.0086250 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
- Chemical Structure
Lab
Chemical Structure - 4-Aminopyridine (4-AP), K+ channel blocker (AB120122)
2D chemical structure image of ab120122, 4-Aminopyridine (4-AP), K+ channel blocker
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취급 방법
Need more advice on solubility, usage and handling? Please visit our our product support page for more details.
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Kv2.2 and its related family members influence the physiological functions of cells by stabilizing resting membrane potential and regulating neurotransmitter release. Kv2.2 channels are often part of larger channel complexes interacting with other proteins to form functional units that respond to changes in membrane potential. These channels significantly affect cellular excitability and signal propagation and are sensitive to pharmacological agents like 4-aminopyridine a known blocker of potassium channels.
Pathways
Kv2.2 channels participate in critical signaling pathways such as those related to neurotransmission and cardiac rhythm maintenance. The MAPK pathway is one area where Kv2.2 functions integrating signals that modulate cell activity. Related proteins include KCNA1 and KCNQ2 which share roles in maintaining electrical gradients and facilitating rapid signaling across excitable membranes.
제품이 사용된 논문 (14)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Neuron 111:2899-2917.e6 PubMed37442130
2023
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Acta pharmacologica Sinica 44:1600-1611 PubMed36973542
2023
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Neuron 110:3036-3052.e5 PubMed35944526
2022
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Neuron 109:1365-1380.e5 PubMed33740416
2021
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Nature 538:383-387 PubMed27732573
2016
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The Journal of neuroscience : the official journal of the Society for Neuroscience 34:15601-9 PubMed25411488
2014
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Frontiers in cellular neuroscience 8:155 PubMed24936172
2014
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PloS one 9:e86250 PubMed24465989
2014
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The Journal of physiology 591:807-22 PubMed23207591
2012
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Proceedings of the National Academy of Sciences of 109:20720-5 PubMed23185019
2012
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Product promise
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