AB120842

5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

Name: 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor
Brand: Abcam Limited
SKU: AB120842
Rating: 5 (1 reviews)

(1 리뷰)

(11 제품이 사용된 논문 )

MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.

1 이미지

Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (AB120842)

Chemical Structure

Lab

Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (AB120842)

2D chemical structure image of ab120842, 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

주요 정보

CAS 번호

2353-33-5

Purity

>99%

제형

Solid

form

Molecular weight

228.21 Da

Molecular formula

C8H12N4O4

PubChem

451668

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in DMSO to 50 mM

생화학적 명칭

Decitabine

생물학적 정보

Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.

Canonical SMILES

C1C(C(OC1N2C=NC(=NC2=O)N)CO)O

Isomeric SMILES

C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O

InChi

InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

InChiKey

XAUDJQYHKZQPEU-KVQBGUIXSA-N

IUPAC Name

4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

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특성 및 보관 정보

배송 시 보관 조건

Ambient - Can Ship with Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store under desiccating conditions|The product can be stored for up to 12 months

취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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제품이 사용된 논문 (11)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncoimmunology 12:2267744 PubMed37868689

2023

() promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Niklas Klümper,Lennert Wüst,Jonas Saal,Damian J Ralser,Romina Zarbl,Jonas Jarczyk,Johannes Breyer,Danijel Sikic,Bernd Wullich,Christian Bolenz,Florian Roghmann,Michael Hölzel,Manuel Ritter,Sebastian Strieth,Arndt Hartmann,Philipp Erben,Ralph M Wirtz,Jennifer Landsberg,Dimo Dietrich,Markus Eckstein

Epigenetics 18:2239607 PubMed37523636

2023

Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yemei Yang,Shengfang Ma,Zi Ye,Yushi Zheng,Zhenjiong Zheng,Xiongshan Liu,Xianyi Zhou

Clinical epigenetics 15:112 PubMed37415208

2023

CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Friederike Hoffmann,Alina Franzen,Luka de Vos,Lennert Wuest,Zsófi Kulcsár,Simon Fietz,Alexander Philippe Maas,Sarah Hollick,Marie Yatou Diop,Jennis Gabrielpillai,Timo Vogt,Pia Kuster,Romina Zarbl,Joern Dietrich,Glen Kristiansen,Peter Brossart,Jennifer Landsberg,Sebastian Strieth,Dimo Dietrich

Life science alliance 6: PubMed37321846

2023

Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yong Kim,Ilian Atanassov,Frederik Dethloff,Lara Kroczek,Thomas Langer

Biomarker research 11:56 PubMed37259155

2023

ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Damian J Ralser,Emmanuelle Herr,Luka de Vos,Zsófi Kulcsár,Romina Zarbl,Niklas Klümper,Gerrit H Gielen,Alexander Philippe Maas,Friederike Hoffmann,Jörn Dietrich,Pia Kuster,Alexander Mustea,Nicole Glodde,Glen Kristiansen,Sebastian Strieth,Jennifer Landsberg,Dimo Dietrich

Clinical epigenetics 14:50 PubMed35410311

2022

DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis Niebel,Anne Fröhlich,Romina Zarbl,Simon Fietz,Luka de Vos,Timo J Vogt,Jörn Dietrich,Judith Sirokay,Pia Kuster,Gonzalo Saavedra,Susana Ramírez Valladolid,Friederike Hoffmann,Sebastian Strieth,Jennifer Landsberg,Dimo Dietrich

British journal of cancer 125:865-876 PubMed34274945

2021

SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Ming-Han Li,Tian-Tian Wang,Xiao-Ning Liu,Xiao-Ting Zhu,Yun-Zhang Dai,Ke-Chao Zhai,Yong-da Liu,Jia-Li Lin,Rui-Liang Ge,Shu-Han Sun,Fang Wang,Ji-Hang Yuan

Journal of virology 93: PubMed30518656

2019

Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Michael R Evans,Claire D James,Molly L Bristol,Tara J Nulton,Xu Wang,Namsimar Kaur,Elizabeth A White,Brad Windle,Iain M Morgan

Cellular physiology and biochemistry : internation 50:1815-1831 PubMed30396168

2018

Secreted Frizzled Related Protein 2 Modulates Epithelial-Mesenchymal Transition and Stemness via Wnt/β-Catenin Signaling in Choriocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xianling Zeng,Yafei Zhang,Huiqiu Xu,Taohong Zhang,Yan Xue,Ruifang An

British journal of cancer 120:115-127 PubMed30382166

2018

VISTA expressed in tumour cells regulates T cell function.

Applications

Unspecified application

Species

Unspecified reactive species

Kumuluzi Mulati,Junzo Hamanishi,Noriomi Matsumura,Kenji Chamoto,Nathan Mise,Kaoru Abiko,Tsukasa Baba,Ken Yamaguchi,Naoki Horikawa,Ryusuke Murakami,Mana Taki,Kharma Budiman,Xiang Zeng,Yuko Hosoe,Miyuki Azuma,Ikuo Konishi,Masaki Mandai

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

Chemical Structure - 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor (AB120842)

주요 정보

CAS 번호

Purity

제형

Molecular weight

Molecular formula

PubChem

Nature

Solubility

생화학적 명칭

생물학적 정보

Canonical SMILES

Isomeric SMILES

InChi

InChiKey

IUPAC Name

보완 제품

Biochemicals

Secondary Antibodies

Primary Antibodies

Primary Antibodies

특성 및 보관 정보

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

취급 방법

제품 프로토콜

제품이 사용된 논문 (11)

Product promise