MW 163.13 Da, Purity >97%. Competitive, reversible and non-selective NOS inhibitor. Neuroprotective, anticonvulsant and anxiolytic in vivo.
대체 명칭 보기
BNOS, Constitutive NOS, EC-NOS, Endothelial NOS, Endothelial nitric oxidase synthase, Endothelial nitric oxide synthase, Endothelial nitric oxide synthase 3, HEP-NOS, Hepatocyte NOS, IHPS 1, Inducible NO synthase, Inducible NOS, Inducible nitric oxide synthase, MAC NOS, Macrophage NOS, N-NOS, NC-NOS, NOS, NOS III, NOS type I, NOS type II, NOS type III, NOS2A, NOS2A, Inducible, Hepatocyte, NOS2_HUMAN, NOS3_HUMAN, Neuronal NOS, Nitric oxide synthase, Nitric oxide synthase 1, Nitric oxide synthase 1 neuronal, Nitric oxide synthase 2 inducible, Nitric oxide synthase 2 inducible macrophage, Nitric oxide synthase 3, Nitric oxide synthase 3 (endothelial cell), Nitric oxide synthase 3 endothelial cell, Nitric oxide synthase brain, Nitric oxide synthase endothelial, Nitric oxide synthase inducible, Nos II, Peptidyl-cysteine S-nitrosylase NOS2, cNOS, eNOS, iNOS, inducible, neuronal Nitric Oxide Synthase, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage
- Chemical Structure
Lab
Chemical Structure - 7-Nitroindazole, NOS inhibitor (AB120233)
2D chemical structure image of ab120233, 7-Nitroindazole, NOS inhibitor
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취급 방법
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The nitric oxide produced by these enzymes is an important signaling molecule involved in numerous physiological processes. eNOS generates NO to regulate vascular tone by promoting vasodilation which is critical for blood pressure control. iNOS unlike eNOS usually appears as a response to inflammatory cytokines and microbial products playing a role in immune defense by producing larger quantities of NO. NOS enzymes often form complexes with other proteins like calmodulin to modulate their activity.
Pathways
Nitric oxide synthase enzymes are essential parts of the nitric oxide pathway significantly affecting cellular signaling and function. eNOS is integral to the endothelial signaling pathway closely interacting with proteins such as AKT and VEGF to influence vascular homeostasis and angiogenesis. iNOS is part of the immune response pathway where its interaction with NF-κB drives immune function under pathological conditions.
Product promise
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