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AB141059

AG-879, TrkA receptor inhibitor

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MW 316.5 Da, Purity >99%. Selective TrkA receptor inhibitor. Inhibits NGF-dependent TrkA phosphorylation (IC50 = 40 μM). Additionally inhibits ErbB2 and the VEGF receptor FLK-1 (IC50 = ~1 μM). Active in vitro and in vivo. Shows antitumor activity.
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Chemical Structure - AG-879, TrkA receptor inhibitor (AB141059)
  • Chemical Structure

Lab

Chemical Structure - AG-879, TrkA receptor inhibitor (AB141059)

2D chemical structure image of ab141059, AG-879, TrkA receptor inhibitor

주요 정보

Purity

>99%

제형

Solid

form

Molecular weight

316.5 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>4</sub>N<sub>2</sub>OS

PubChem

5487525

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

생화학적 명칭

CID 5487525

생물학적 정보

Selective TrkA receptor inhibitor. Inhibits NGF-dependent TrkA phosphorylation (IC50 = 40 μM). Additionally inhibits ErbB2 and the VEGF receptor FLK-1 (IC50 = ~1 μM). Active in vitro and in vivo. Shows antitumor activity.

Canonical SMILES

CC(C)(C)C1=CC(=CC(=C(N)S)C#N)C=C(C1=O)C(C)(C)C

Isomeric SMILES

CC(C)(C)C1=CC(=C/C(=C(/N)\S)/C#N)C=C(C1=O)C(C)(C)C

InChi

InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+

InChiKey

LCUMYVYIHXYBIA-FOWTUZBSSA-N

IUPAC Name

(E)-3-amino-2-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile

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보완 제품

Biochemicals

AB141254

DBeQ, p97 ATPase inhibitor

Chemical Structure - DBeQ, p97 ATPase inhibitor (AB141254)

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Biochemicals

AB146196

ANA-12, TrkB antagonist

Chemical Structure - ANA-12, TrkB antagonist (AB146196)

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Primary Antibodies

AB18207

Anti-beta III Tubulin antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody - Neuronal Marker (AB18207)

  • 5
  • 67
Biochemicals

AB282436

Ro 08-2750

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  • 0
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특성 및 보관 정보

배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Store under desiccating conditions|The product can be stored for up to 12 months
취급 방법

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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제품 프로토콜

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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