AMN082 dihydrochloride, mGlu7 agonist

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(11 제품이 사용된 논문 )

MW 465.5 Da, Purity >98%. Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones *in vivo*. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.

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AMPA-selective glutamate receptor 2, CSNB1B, DKFZp686H1993, FLJ40498, FLJ41058, GLUR, GLUR8, GPRC1A, GPRC1B, GPRC1C, GPRC1D, GPRC1E, GPRC1F, GPRC1G, GPRC1H, GRM1-Alpha, GRM1_HUMAN, GRM2_HUMAN, GRM3_HUMAN, GRM4_HUMAN, GRM5_HUMAN, GRM6_HUMAN, GRM7_HUMAN, GRM8_HUMAN, GluR-2, GluR-3, GluR-6, GluR-7, GluR-B, Glutamate metabotropic receptor 2, Glutamate metabotropic receptor 3, Glutamate receptor homolog, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, Glutamate receptor metabotropic 4, Glutamate receptor metabotropic 5, Glutamate receptor metabotropic 6, Glutamate receptor metabotropic 7, Glutamate receptor metabotropic 8, MGC126724, MGLU1, MGLU7, MGLUR2, MGLUR3, MGLUR6, MGlu3, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Metabotropic glutamate receptor 6, Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 8, OTTHUMP00000206961, OTTHUMP00000210984, OTTHUMP00000210986, OTTHUMP00000214674, OTTHUMP00000214675, PPP1R86, Protein phosphatase 1 regulatory subunit 86, SCAR13, Smp_128940, mGlu2, mGlu4, mGlu5, mGlu6, mGlu8, mGluR1, mGluR4, mGluR5, mGluR7